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The Role of Long Non-Coding RNAs in Cardiovascular Diseases
1Biotechnology Department, Ho Chi Minh City Open University, Ho Chi Minh City 70000, Vietnam.
International Journal of Molecular Sciences
|September 28, 2023
Summary
Long non-coding RNAs (lncRNAs) regulate gene expression and are implicated in various diseases. Understanding lncRNA roles in cardiovascular diseases (CVDs) may improve diagnostics and treatments.
Area of Science:
- Molecular Biology
- Genetics
- Cardiology
Background:
- Long non-coding RNAs (lncRNAs) are key regulators of gene expression.
- Aberrant lncRNA expression is linked to numerous human diseases, including cardiovascular diseases (CVDs).
- CVDs represent a leading global cause of mortality.
Purpose of the Study:
- To review the function and involvement of lncRNAs in the pathogenesis of various cardiovascular diseases.
- To discuss the potential clinical applications of lncRNAs in diagnosing, predicting, and treating CVDs.
Main Methods:
- Literature review and synthesis of existing research on lncRNAs in cardiovascular biology.
- Analysis of lncRNA roles in specific CVDs such as atherosclerosis, myocardial infarction, hypertrophy, and heart failure.
Main Results:
- lncRNAs play critical roles in cardiac development and function.
- Dysregulation of specific lncRNAs is associated with the progression of diverse cardiovascular conditions.
- lncRNAs exhibit potential as biomarkers and therapeutic targets for CVDs.
Conclusions:
- lncRNAs are integral to cardiovascular homeostasis and disease development.
- Further research into lncRNA mechanisms can unlock novel diagnostic and therapeutic strategies for cardiovascular diseases.
- Targeting lncRNAs holds promise for future clinical interventions in cardiology.
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