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Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review

Ka Young Kim1,2, Ki Young Shin3, Keun-A Chang2,4

  • 1Department of Nursing, College of Nursing, Gachon University, Incheon 21936, Republic of Korea.

International Journal of Molecular Sciences
|September 28, 2023
PubMed

Insights

Major depressive disorder (MDD) is linked to increased suicide risk. This study identified 43 inflammatory biomarkers, including interleukin-6 and C-reactive protein, associated with suicidal behavior in MDD patients.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Immunology

Background:

  • Major depressive disorder (MDD) affects 280 million globally and carries the highest suicide risk among psychiatric conditions.
  • Depression and suicidal ideation are linked to inflammatory processes.
  • Identifying reliable biomarkers for suicide risk in MDD is crucial for clinical intervention.

Purpose of the Study:

  • To identify peripheral inflammatory biomarkers associated with suicide-related behaviors in patients with MDD.
  • To synthesize evidence from existing literature on the role of inflammation in MDD and suicidality.

Main Methods:

  • Systematic literature search of PubMed, Embase, Web of Science, and Cochrane Library for studies published before June 2023.
  • Inclusion of studies reporting blood inflammatory biomarkers in MDD patients with suicide-related behaviors.
  • Analysis of 24 selected studies out of 571 initially identified.

Main Results:

  • Identification of 43 significant biomarkers associated with MDD and suicide-related behaviors.
  • Significant alterations in peripheral inflammatory factors were observed in MDD patients with suicide-related behaviors.
  • Key biomarkers include interleukin (IL)-1β, IL-6, C-reactive protein, C-C motif chemokine ligand 2, and tumor necrosis factor-α.

Conclusions:

  • Peripheral inflammatory factors are significantly altered in MDD patients exhibiting suicide-related behaviors.
  • Specific biomarkers like IL-1β, IL-6, CRP, CCL2, and TNF-α show potential for indicating suicide risk in MDD.
  • These findings highlight the complex interplay between inflammation and suicidal risk in major depressive disorder.
Keywords:
blood biomarkerinflammationmajor depressive disordersuicidal behavior

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