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Applications of Genome Editing Technologies in CAD Research and Therapy with a Focus on Atherosclerosis

Michelle C E Mak1, Rijan Gurung1, Roger S Y Foo1

  • 1Cardiovascular Research Institute, Cardiovascular and Metabolic Disease Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, 14 Medical Drive, MD6, #08-01, Singapore 117599, Singapore.

International Journal of Molecular Sciences
|September 28, 2023
PubMed

Insights

Genome editing offers new ways to model atherosclerosis, a key driver of cardiovascular diseases like coronary artery disease. This technology also shows promise for developing novel therapies to treat these widespread and often fatal conditions.

Area of Science:

  • Genetics and Genomics
  • Cardiovascular Medicine
  • Biotechnology

Background:

  • Cardiovascular diseases (CVDs), especially coronary artery disease (CAD), are the leading global cause of mortality.
  • Atherosclerosis is a primary pathological process underlying CAD, necessitating further research for effective treatments.
  • Existing therapeutic strategies for atherosclerosis and CAD require enhancement and innovation.

Purpose of the Study:

  • To review the application of genome editing technologies in creating models of atherosclerosis.
  • To explore the therapeutic potential of genome editing for atherosclerosis and its clinical implications in CAD.
  • To highlight advancements in understanding and treating CAD through genetic manipulation.

Main Methods:

  • Review of current literature on genome editing applications in cardiovascular research.
  • Analysis of studies utilizing genome editing for atherosclerosis model development.
  • Examination of therapeutic strategies employing genome editing for CAD and atherosclerosis.

Main Results:

  • Genome editing tools facilitate the precise creation of cellular and animal models of atherosclerosis.
  • These models aid in dissecting the molecular mechanisms driving atherosclerosis.
  • Emerging evidence suggests genome editing holds therapeutic promise for genetic components of atherosclerosis and CAD.

Conclusions:

  • Genome editing is a powerful tool for advancing atherosclerosis research and developing disease models.
  • Therapeutic applications of genome editing in CAD and atherosclerosis are promising areas for future clinical development.
  • Further research is warranted to translate these genetic technologies into effective clinical interventions.

Keywords:
CRISPRTALENZFNatherosclerosiscoronary artery diseasegenome editing

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