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Inflammatory Cytokines Are Associated with Cognitive Dysfunction and Depressive State during Acute Bacterial
Mónica Arias-Colinas1,2, Alfredo Gea1,2,3, Ahmed Khattab4
1Department of Preventive Medicine and Public Health, University of Navarra, 31008 Pamplona, Spain.
International Journal of Molecular Sciences
|September 28, 2023
Summary
During bacterial infections, inflammatory markers like C-reactive protein (CRP) and interleukin-6 (IL6) significantly influence sickness behavior and cognitive function. Reducing these inflammation markers aids recovery and improves mental well-being.
Area of Science:
- Neuroscience
- Immunology
- Psychiatry
Background:
- Sickness behavior, characterized by behavioral changes during infection, is linked to inflammatory markers.
- Few studies have investigated sickness behavior in real-world infection scenarios.
Purpose of the Study:
- To explore the role of inflammatory cytokines in mediating sickness behavior during bacterial infections.
- To assess the relationship between inflammatory markers and cognitive/depressive states.
Main Methods:
- A longitudinal observational study followed 61 participants (infection, hospital control, healthy groups) for 6 weeks.
- Quantified inflammatory markers (CRP, IL6, TNFα, IL4) and assessed cognitive function (MMSE) and depression (CSDD).
Main Results:
- Reduced pro-inflammatory markers (CRP, IL6, TNFα) and increased anti-inflammatory markers (IL4) correlated with improved CSDD and MMSE scores.
- Significant correlations were found between CRP, IL6, TNFα, IL4, and CSDD scores.
Conclusions:
- Inflammatory cytokines appear to mediate sickness behavior during acute bacterial illness.
- Findings may inform pathophysiology understanding and treatment strategies for sickness behavior.
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