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Related Concept Videos

Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

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The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Related Experiment Video

Updated: Jul 15, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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The Roles of microRNAs in the Cardiovascular System.

Francesco Nappi1, Sanjeet Singh Avtaar Singh2, Vikram Jitendra3

  • 1Department of Cardiac Surgery, Centre Cardiologique du Nord, 93200 Saint-Denis, France.

International Journal of Molecular Sciences
|September 28, 2023
PubMed
Summary

MicroRNAs (miRNAs) show promise for diagnosing and treating cardiovascular diseases. Further research and clinical trials are exploring their potential to improve patient outcomes and address limitations in current therapies.

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acute coronary syndromecoronary artery diseasemiRNA biomarkermicroRNAmicroRNA functions

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Area of Science:

  • Biochemistry and Molecular Biology
  • Cardiology
  • Translational Medicine

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression with significant roles in various diseases.
  • Cardiovascular diseases (CVDs) present challenges in early diagnosis and conventional treatment.
  • miRNAs offer potential as novel diagnostic and therapeutic targets for CVDs.

Purpose of the Study:

  • To review the current understanding of miRNAs in cardiovascular disease.
  • To highlight recent advances in miRNA research for clinical translation.
  • To discuss challenges and future perspectives for miRNA-based cardiovascular therapies.

Main Methods:

  • Literature review of preclinical and clinical studies on miRNAs in cardiovascular diseases.
  • Analysis of current research on miRNA recognition, characterization, and clinical application.
  • Discussion of diagnostic and therapeutic potential of miRNAs in acute coronary syndromes.

Main Results:

  • miRNAs are emerging as promising biomarkers for diagnosing and predicting acute coronary syndromes.
  • miRNA-based drugs demonstrate significant potential for cardiovascular disease treatment.
  • Clinical trials show progress, indicating a promising future for miRNA applications.

Conclusions:

  • miRNAs hold substantial promise for revolutionizing cardiovascular disease diagnosis and therapy.
  • Further research and clinical validation are crucial for widespread adoption.
  • miRNA-based approaches may soon complement or enhance existing diagnostic and therapeutic strategies.