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Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
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Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

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Alpha-Linolenic Acid and Cardiovascular Events: A Narrative Review

Camilla Bertoni1, Martina Abodi1, Veronica D'Oria2

  • 1Department of Veterinary Sciences for Health, Animal Production and Food Safety, University of Milan, 20122 Milan, Italy.

International Journal of Molecular Sciences
|September 28, 2023
PubMed

Insights

Alpha-linolenic acid (ALA), an omega-3 fatty acid, can help lower cholesterol and triglycerides, reducing cardiovascular disease (CVD) risk. Dietary ALA also offers cardioprotective benefits, aiding in blood pressure management.

Area of Science:

  • Nutrition Science
  • Cardiology
  • Public Health

Background:

  • Cardiovascular diseases (CVDs) are the leading cause of global mortality.
  • Drug therapy is a primary intervention, but alternative strategies are sought.
  • Alpha-linolenic acid (ALA), an omega-3 fatty acid, is recognized for its cholesterol-lowering properties.

Purpose of the Study:

  • To review the effects of ALA on cardiovascular health.
  • To investigate the optimal omega-6/omega-3 ratio for beneficial effects.
  • To assess ALA's role in lipid management and blood pressure regulation.

Main Methods:

  • Literature review of studies on ALA and cardiovascular markers.
  • Analysis of data concerning LDL-C, triglycerides, and blood pressure.
  • Consideration of EFSA (European Food Safety Authority) statements.

Main Results:

  • ALA favorably impacts LDL-C and triglyceride levels in adults and children.
  • Dietary ALA contributes to blood pressure balance, offering anti-hypertensive effects.
  • ALA demonstrates anti-atherosclerotic and cardioprotective properties.

Conclusions:

  • Dietary ALA can be an effective alternative or complementary strategy to reduce CVD risk.
  • Maintaining an appropriate omega-6/omega-3 ratio is crucial for cardiovascular benefits.
  • ALA intake supports overall cardiovascular health through multiple mechanisms.

Keywords:
LDL-cholesterolTC-cholesterolalpha-linolenic acidcardioprotective effectcardiovascular eventsheart disordershempseed oillinoleic acid

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