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Nanoparticle-Based Treatment in Glioblastoma.

Diogo Roque1,2, Nuno Cruz3,4, Hugo Alexandre Ferreira3

  • 1Department of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHULN), 1649-028 Lisbon, Portugal.

Journal of Personalized Medicine
|September 28, 2023
PubMed
Summary

Polymeric nanoparticles show promise for glioblastoma (GB) treatment by crossing the blood-brain barrier (BBB) to improve drug delivery. Further pre-clinical studies are crucial for advancing these novel nanoparticle therapies for brain cancer.

Keywords:
blood-brain barrierglioblastomananoparticlestherapy delivery

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Area of Science:

  • Neuro-oncology
  • Nanomedicine
  • Drug Delivery Systems

Background:

  • Glioblastoma (GB) has a poor prognosis with a median survival of 12-18 months, characterized by high relapse rates and treatment resistance.
  • Standard treatment involves surgery, radiotherapy, and chemotherapy, but drug efficacy is limited by the blood-brain barrier (BBB).

Purpose of the Study:

  • To review recent literature on nanoparticle-based therapies for glioblastoma treatment.
  • To highlight the potential of polymeric nanoparticles in overcoming BBB limitations for improved glioblastoma therapy.

Main Methods:

  • Review of pre-clinical studies focusing on polymeric nanoparticles for glioblastoma treatment.
  • Analysis of nanoparticle strategies designed to cross the BBB and enhance drug delivery to the brain.

Main Results:

  • Polymeric nanoparticles demonstrate potential for targeted brain drug delivery, minimizing systemic toxicity and degradation.
  • Various nanoparticle-based drug delivery methods are under investigation in vitro and in vivo.
  • Few nanoparticle systems have progressed to clinical trials, emphasizing the importance of pre-clinical research.

Conclusions:

  • Nanoparticle-based treatments, particularly polymeric nanoparticles, offer a promising avenue for improving glioblastoma patient outcomes.
  • Continued pre-clinical research is essential to validate the safety and efficacy of these novel therapies before clinical application.