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Defining Substrate Specificities for Lipase and Phospholipase Candidates
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Redox Modification of PKA-Cα Differentially Affects Its Substrate Selection

Jeannette Delva-Wiley1, Ese S Ekhator1, Laquaundra L Adams1

  • 1Department of Biology, North Carolina A&T State University, Greensboro, NC 27411, USA.

Life (Basel, Switzerland)
|September 28, 2023
PubMed
Summary

Redox modification of cyclic AMP-dependent protein kinase alpha (PKA-Cα) alters its substrate specificity. Oxidation impacts PKA-Cα activity differently across various substrates, revealing crosstalk between redox and phosphorylation signaling.

Keywords:
cAMP-dependent protein kinase (PKA)oxidationphosphorylation-dependent signalingprotein kinasereactive oxygen speciesredox signaling

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