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Carbon Skeletons01:12

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Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side chains...

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Flurona: The First Autopsied Case.

Ionuț Isaia Jeican1, Dan Gheban2,3, Alexandra Mariș4

  • 1Department of Anatomy and Embryology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.

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Summary

Flurona, a coinfection of influenza and SARS-CoV-2, can be fatal, especially in infants. This case highlights the severe lung inflammation and multi-organ failure caused by this dual viral respiratory infection.

Keywords:
COVID-19autopsyfluronainfluenza

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Area of Science:

  • Pediatric Infectious Diseases
  • Respiratory Virology
  • Immunopathology

Background:

  • Coinfections with COVID-19 increase disease severity and mortality.
  • The term "flurona" describes coinfection with influenza and SARS-CoV-2.
  • Dual respiratory viral infections pose significant clinical challenges.

Observation:

  • A fatal case of flurona in a 7-month-old infant is reported.
  • Histopathology revealed significant lung inflammation, diffuse alveolar damage, and vasculitis.
  • Immune cell infiltration, including CD45+, CD20+, and CD3+ cells, was observed in lung tissues.

Findings:

  • Flurona coinfection led to extensive lung inflammation and respiratory failure.
  • The combined viral aggression resulted in multiple organ failure and death.
  • Histopathological analysis confirmed tissue damage from both influenza and SARS-CoV-2, without dominance of one virus.

Implications:

  • This case underscores the critical risk associated with flurona coinfection in vulnerable populations.
  • Understanding the immunopathology of dual infections is crucial for developing effective treatments.
  • Further research is needed to elucidate the synergistic effects of coinfecting respiratory viruses.