Jove
Visualize
Contact Us

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Curcumin-based-fluorescent staining and microfluidic detection of microplastics in wastewater effluent.

Chemical communications (Cambridge, England)·2025
Same author

Electrochemical microfluidic sensor with sodium ion-imprinted polymer membrane for sensitive and specific detection of sodium in water.

Mikrochimica acta·2025
Same author

Parallelization of Curved Inertial Microfluidic Channels to Increase the Throughput of Simultaneous Microparticle Separation and Washing.

Micromachines·2024
Same author

Simultaneous high-throughput particle-bacteria separation and solution exchange via in-plane and out-of-plane parallelization of microfluidic centrifuges.

Biomicrofluidics·2024
Same author

Electrochemical Impedance Spectroscopy-Based Microfluidic Biosensor Using Cell-Imprinted Polymers for Bacteria Detection.

Biosensors·2024
Same author

Fabrication of Porous Collagen Scaffolds Containing Embedded Channels with Collagen Membrane Linings.

Micromachines·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 15, 2025

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology
07:03

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

943

Microfluidic Droplet-Generation Device with Flexible Walls.

Sajad Yazdanparast1, Pouya Rezai1, Alidad Amirfazli1

  • 1Department of Mechanical Engineering, York University, Toronto, ON M3J 1P3, Canada.

Micromachines
|September 28, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed a flexible microfluidic device for precise droplet size control. This innovation enables a wider range of droplet sizes from a single apparatus, advancing applications in drug discovery and manufacturing.

Keywords:
co-flow methoddroplet-size controlflexible wallsmicrofluidics droplet generation

More Related Videos

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
08:20

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

10.4K
Fluorescence detection methods for microfluidic droplet platforms
14:16

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

22.2K

Related Experiment Videos

Last Updated: Jul 15, 2025

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology
07:03

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

943
Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
08:20

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

10.4K
Fluorescence detection methods for microfluidic droplet platforms
14:16

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

22.2K

Area of Science:

  • Microfluidics
  • Fluid Dynamics
  • Biomedical Engineering

Background:

  • Precise control of droplet size is critical for biomedical research, drug discovery, high-throughput screening, and emulsion manufacturing.
  • Current droplet generation devices often have limited ranges of droplet sizes and require multiple setups.

Purpose of the Study:

  • To develop a single co-flow microfluidic device with adjustable channel width for flexible droplet size control.
  • To investigate the impact of channel width on droplet generation regimes and sizes.

Main Methods:

  • A co-flow microfluidic device with adjustable flexible walls was designed and fabricated.
  • The continuous (C)-phase channel width was varied to modulate flow velocity and viscous forces.
  • Droplet generation regimes (dripping and plug) were observed, and droplet sizes were measured across different channel widths and flow conditions.

Main Results:

  • Adjusting the channel width allowed for on-demand modulation of droplet sizes within a single device.
  • Two regimes, dripping and plug, were identified based on channel width and low dispersed (D)-phase Weber numbers.
  • Reducing channel width, particularly at a constant C-phase flow rate, resulted in smaller droplets due to wall effects and increased C-phase velocity.
  • A droplet size range of 175–913 µm was achieved, significantly wider than existing single-device capabilities.

Conclusions:

  • The developed microfluidic device offers a versatile platform for generating a broad spectrum of droplet sizes.
  • An empirical model based on Buckingham's Pi theorem was established to predict droplet size, incorporating channel dimensions and flow parameters.