Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abnormal cilia in a malignant ependymoma.

T Kubota, J Ishise, T Yamashima

    Acta Neuropathologica
    |January 1, 1986
    PubMed
    Summary

    Electron microscopy revealed abnormal cilia in a cerebellar vermis ependymoma. Giant compound cilia with disorganized microtubules and cavities were frequently observed, suggesting unique cellular pathology.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Traumatic atlanto-occipital dislocation with long-term survival.

    Neurologia medico-chirurgica·1996
    Same author

    Status asthmaticus complicated by atelectasis in a child.

    The American journal of emergency medicine·1995
    Same author

    Power spectral analysis of heart rate and arterial blood pressure oscillation in brain-dead patients.

    Journal of the autonomic nervous system·1993
    Same author

    Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene.

    The Journal of biological chemistry·1992
    Same author

    Further studies on aspartate aminotransferase of thermophilic methanogens by analysis of general properties, bound cofactors, and subunit structures.

    Journal of biochemistry·1992
    Same author

    Characterization of saccharide moiety in the electroplax sodium channel.

    Chemical & pharmaceutical bulletin·1992

    Area of Science:

    • * Cell Biology
    • * Neuro-oncology
    • * Electron Microscopy

    Background:

    • * Ependymomas are tumors arising from ependymal cells in the central nervous system.
    • * Cilia are microtubule-based cellular appendages crucial for motility and sensory functions.
    • * Ultrastructural analysis is vital for understanding cellular abnormalities in tumors.

    Observation:

    • * Electron microscopy identified frequent abnormal cilia in a malignant ependymoma of the cerebellar vermis.
    • * Observed abnormalities included compound cilia with giant axonemes and bizarre shapes.
    • * These giant cilia exhibited random microtubular doublet orientation and internal cavities.

    Findings:

    • * Abnormal cilia displayed disorganized microtubular arrangements, including random peripheral doublet and central singlet configurations.
    • * Compound cilia with significantly enlarged axonemes and complex internal structures were a prominent feature.
    • * The study provides detailed ultrastructural evidence of ciliary dysmorphia in this specific tumor type.

    Implications:

    • * Understanding these ciliary abnormalities may offer insights into ependymoma pathogenesis.
    • * The findings could potentially inform the development of novel diagnostic or therapeutic strategies targeting ciliary structure or function.
    • * Further research into the formation process of these abnormal cilia is warranted.

    Related Experiment Videos