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Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

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Urolithins: A Prospective Alternative against Brain Aging.

Lei An¹, Qiu Lu¹, Ke Wang^1,2,3

¹Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Technology and Business University, Beijing 100048, China.

|September 28, 2023

Summary

Urolithins (Uros), gut microbial metabolites, show promise for preventing brain aging and neurodegenerative diseases due to their brain-penetrating properties. Further research is needed to establish their clinical use as functional foods or drugs.

Keywords:

aging brain metabolites microbial-derived neurodegenerative diseases urolithin

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Area of Science:

Microbiology
Neuroscience
Metabolomics

Background:

Host-microbiome interactions significantly impact cognitive health and disease.
Gut-derived microbial metabolites are key mediators of the gut-brain axis.
Urolithins (Uros) are microbial metabolites of ellagitannins with variable biotransformation and age-related decline.

Purpose of the Study:

To review the achievements of Urolithins in age-related brain dysfunction and neurodegenerative diseases.
To discuss the prospects and knowledge gaps of Urolithins as functional food, drugs, or biomarkers for brain aging.

Main Methods:

Comprehensive literature review of preclinical and clinical studies.
Analysis of Urolithins' properties including blood-brain barrier permeability and brain distribution.
Evaluation of Urolithins' potential in diagnosis, prevention, and treatment.

Main Results:

Accumulating evidence suggests Urolithins possess advantages in preventing brain aging.
Urolithins exhibit favorable blood-brain barrier permeability and selective brain distribution.
Preclinical and clinical data increasingly support Urolithins' neuroprotective effects.

Conclusions:

Urolithins demonstrate significant potential in combating age-related brain dysfunction and neurodegenerative diseases.
Further investigation is required to fully elucidate the clinical utility of Urolithins.
Urolithins may serve as valuable functional foods, drugs, or biomarkers against brain aging.