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The Mother-Child Dyad Adipokine Pattern: A Review of Current Knowledge

Jolanta Lis-Kuberka1, Małgorzata Pupek1, Magdalena Orczyk-Pawiłowicz1

  • 1Department of Biochemistry and Immunochemistry, Division of Chemistry and Immunochemistry, Wroclaw Medical University, M. Skłodowskiej-Curie 48/50, 50-369 Wroclaw, Poland.

Nutrients
|September 28, 2023
PubMed

Insights

Adipokines, hormones regulating metabolism, are crucial in mother-child health. Their altered levels during pregnancy impact offspring

Area of Science:

  • Endocrinology
  • Metabolism
  • Perinatal Health

Background:

  • Adipokines are adipose tissue hormones vital for metabolic regulation.
  • Maternal adipokine alterations negatively affect insulin resistance, metabolic stress, placental function, and fetal development.
  • These changes can lead to long-term metabolic health issues in offspring.

Purpose of the Study:

  • To review current knowledge on adipokine concentrations in maternal-infant dyads.
  • To examine the impact of perinatal risk factors on adipokine patterns.
  • To identify knowledge gaps in perinatal and postnatal metabolic programming.

Main Methods:

  • Literature review of studies measuring adipokines in maternal plasma, cord plasma, infant plasma, milk, and placenta.
  • Analysis of data concerning gestational diabetes mellitus, preeclampsia, intrauterine growth restriction, preterm delivery, and maternal obesity.
  • Synthesis of findings on adipokine profiles in various biological fluids.

Main Results:

  • Adipokine patterns are significantly influenced by adverse perinatal risk factors.
  • Specific adipokines show altered concentrations in maternal and infant biological fluids under conditions like gestational diabetes and obesity.
  • The review highlights substantial variability and knowledge gaps in adipokine dynamics.

Conclusions:

  • Adipokine measurement in maternal-infant dyads is critical for preventing metabolic diseases.
  • Further research is needed to understand adipokine roles in early developmental programming.
  • Maternal lifestyle interventions may offer a pathway to modulate adverse metabolic outcomes.

Keywords:
adipokinesgestational diabetes mellitushuman milklifestyle diseasesmaternal and cord plasmamother–child dyadnewborn/infant plasmaobesity

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