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Updated: Jul 15, 2025

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

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Practical Approach to Hypersensitivity to Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Children

Daniela Podlecka1, Anna Socha-Banasiak2, Joanna Jerzynska1

  • 1Department of Pediatrics and Allergy, Copernicus Memorial Hospital in Lodz, Medical University of Lodz, 90-419 Lodz, Poland.

Pharmaceuticals (Basel, Switzerland)
|September 28, 2023
PubMed

Insights

Non-steroidal anti-inflammatory drug (NSAID) hypersensitivity affects 30.1% of children presenting with adverse reactions. Ibuprofen-induced hypersensitivity commonly causes urticaria and angioedema, with vitamin D deficiency as a risk factor.

Area of Science:

  • Pediatric Allergy and Immunology
  • Pharmacovigilance
  • Clinical Diagnostics

Background:

  • Assessing real-world prevalence of drug hypersensitivity to NSAIDs in children.
  • Characterizing patient profiles and clinical presentations post-adverse event.
  • Utilizing drug challenge tests for verification.

Purpose of the Study:

  • To determine the prevalence of NSAID hypersensitivity in children.
  • To identify patient demographics and clinical signs of NSAID hypersensitivity.
  • To explore risk factors associated with NSAID hypersensitivity.

Main Methods:

  • Inclusion of 56 children (aged 4-18) with suspected adverse reactions to NSAIDs.
  • Performance of skin prick tests and drug provocation tests.
  • Diagnostic workup for persistent urticaria.

Main Results:

  • NSAID hypersensitivity confirmed in 30.1% of patients (17/56).
  • Angioedema and urticaria were the most frequent manifestations (84.9%).
  • Ibuprofen was the most common NSAID involved; vitamin D deficiency was a significant risk factor (OR=5.76).

Conclusions:

  • NSAID hypersensitivity presents diagnostic challenges in pediatric allergy.
  • Acute urticaria and angioedema are key indicators of ibuprofen hypersensitivity in children.
  • Vitamin D levels and viral infections warrant further investigation as potential cofactors.
Abstract

Keywords:
NSAIDsangioedemachildrenhypersensitivityurticaria

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