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Metabolomic Profile, Plasmatic Levels of Losartan and EXP3174, Blood Pressure Control in Hypertensive Patients and

Kamila A Queiroz1,2, Everton P Vale2,3, Manuel Martín-Pastor4

  • 1Graduate Program on Pharmaceutical Sciences, Department of Biological & Health Sciences, Federal University of Amapa, Macapa 68903-419, Brazil.

Pharmaceuticals (Basel, Switzerland)
|September 28, 2023
PubMed

Insights

COVID-19 significantly impacts the metabolomic profile of hypertensive patients, affecting blood pressure control and medication effectiveness. Metabolomics reveals key biomarkers indicating metabolic changes and organ damage in these patients.

Area of Science:

  • Biochemistry
  • Cardiology
  • Infectious Diseases

Background:

  • Systemic arterial hypertension (SAH) is a prevalent global chronic disease with severe health implications.
  • SAH is a significant risk factor for COVID-19, complicating patient outcomes.
  • Understanding the interplay between SAH, COVID-19, and metabolic profiles is crucial for patient management.

Purpose of the Study:

  • To investigate the impact of COVID-19 on the metabolomic profile of hypertensive patients.
  • To correlate metabolic profiles with losartan (LOS) and EXP3174 levels, biochemical markers, and blood pressure (BP) control.
  • To identify biomarkers associated with SAH and COVID-19 in hypertensive individuals.

Main Methods:

  • Utilized 1H NMR spectroscopy to analyze metabolomic profiles of hypertensive and normotensive patients with and without prior COVID-19.
  • Correlated plasma levels of losartan and its metabolite EXP3174 with BP, biochemical markers, and metabolomic data.
  • Identified specific metabolites indicative of metabolic alterations and organ damage.

Main Results:

  • Identified key metabolites (glucose, glutamine, arginine, creatinine, etc.) linked to SAH and COVID-19, indicating metabolic alterations, kidney damage, and inflammation.
  • Observed suboptimal therapeutic levels of losartan and EXP3174 in some hypertensive patients.
  • Noted limited blood pressure control in normotensive patients with a history of COVID-19.

Conclusions:

  • Metabolomics is a valuable tool for evaluating losartan pharmacotherapy effectiveness in hypertensive patients.
  • Metabolomic profiling can help assess the damage caused by SAH and COVID-19.
  • Identified biomarkers highlight the complex metabolic consequences of co-existing SAH and COVID-19.

Keywords:
COVID-19EXP3174hypertensionlosartanmetabolomicsplasmatic level

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