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Evaluation of Different Doses in Inhaled Therapy: A Comprehensive Analysis
José Luis Lopez-Campos1,2, Rocio Reinoso-Arija1, Marta Ferrer Galván1
1Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla, IBiS, Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, 41013 Seville, Spain.
Pharmaceutics
|September 28, 2023
Summary
Dosage confusion for inhaled medications is common. This study found up to four different doses for single inhaled drugs, highlighting the need for clinician awareness when prescribing these respiratory therapies.
Area of Science:
- Pharmacology
- Respiratory Medicine
- Drug Delivery Systems
Background:
- Significant confusion exists regarding the appropriate dosages for inhaled medications.
- Inhalation therapy devices are widely used for various respiratory conditions.
Purpose of the Study:
- To review and clarify the dosages of medications delivered via inhalation therapy devices.
- To address the discrepancies in drug dosing information for inhaled products.
Main Methods:
- Systematic search of inhalation devices listed on the Spanish Ministry of Health Billing List (July 2023).
- Consultation with the Spanish Agency for Medicines and Health Products for official labeling and composition details.
Main Results:
- Identified 90 unique inhaled products: 22 bronchodilators and 68 inhaled corticosteroids (ICS).
- Dosing was marketed as metered dose (10 bronchodilators, 40 ICS) or delivered dose (11 bronchodilators, 28 ICS).
- Inconsistent drug nomenclature (salt vs. base form) was observed for some bronchodilators.
Conclusions:
- Each inhaled drug may be available in up to four different doses.
- The marketed product name can correspond to any of these varying dosages.
- Clinicians must exercise caution and be fully aware of dosage variations when prescribing inhaled medications.
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