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Phases of Wound Repair01:28

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
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Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
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Mesoporous Composite Bioactive Compound Delivery System for Wound-Healing Processes.

Bogdan Purcăreanu1,2, Manuela Diana Ene1, Alina Moroșan3

  • 1Biotehnos SA, Gorunului Street 3-5, 075100 Otopeni, Romania.

Pharmaceutics
|September 28, 2023
PubMed
Summary

This study developed a novel mesoporous silica composite (MCM-41) loaded with Salvia officinalis and Calendula officinalis extracts for advanced wound healing. The composite effectively promotes tissue regeneration by stimulating collagen synthesis and cell migration.

Keywords:
MCM-41bioactive extractbiological activitycompositesmesoporous materialwound healing

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Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Wound treatment faces challenges due to complications and social impact, driving the need for advanced biocompatible medicines.
  • Mesoporous materials loaded with natural bioactive compounds offer potential for wound healing due to low toxicity, high drug loading, and controlled release.
  • MCM-41-type mesoporous silica, synthesized using sodium trisilicate, presents a promising scaffold for drug delivery.

Purpose of the Study:

  • To synthesize and characterize MCM-41 mesoporous silica.
  • To load MCM-41 with Salvia officinalis (SO) and Calendula officinalis (CO) extracts, creating a novel MCM-41/SO&CO composite.
  • To evaluate the wound-healing potential of the synthesized composite by assessing its effects on cellular processes involved in tissue regeneration.

Main Methods:

  • MCM-41 synthesis via sodium trisilicate at room temperature and pressure.
  • Characterization using SEM, TEM, BET, DLS, and FT-IR to confirm material properties (high surface area, ordered pores).
  • Quantification of active compounds (ursolic acid, oleanolic acid, polyphenols, flavones) using HPLC-DAD and LC-MS-MS; biological evaluation on HS27 and HaCaT cell lines.

Main Results:

  • The synthesized MCM-41 exhibited a high surface area (1244 m²/g), ~2 nm pore diameter, and ordered hexagonal structure.
  • The MCM-41/SO&CO composite demonstrated the ability to stimulate collagen biosynthesis.
  • The composite enhanced metalloproteinase activity (MMP-2, MMP-9) and cell migration rates, indicating re-epithelializing properties.

Conclusions:

  • The developed MCM-41/SO&CO composite shows significant potential as an advanced wound healing agent.
  • The composite's ability to modulate key cellular processes supports its efficacy in promoting tissue regeneration and re-epithelialization.
  • This research provides a foundation for developing novel biomaterials for improved wound management strategies.