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The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances

Hanxiao Li1, Junhui Niu1, Xiaoli Wang2

  • 1Luoyang Key Laboratory of Live Carrier Biomaterial and Anmal Disease Prevention and Control, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.

Pharmaceutics
|September 28, 2023
PubMed

Insights

Antimicrobial peptides (AMPs) show promise as alternatives to antibiotics, exhibiting potent anti-inflammatory and immunomodulatory effects. This review details AMP mechanisms in various immune cells, highlighting their therapeutic potential for inflammatory diseases.

Area of Science:

  • Immunology
  • Pharmacology
  • Biochemistry

Background:

  • The rise of multidrug-resistant microorganisms necessitates novel antimicrobial agents.
  • Antimicrobial peptides (AMPs) are a promising class of compounds with broad-spectrum antimicrobial, anticancer, and immunomodulatory activities.
  • AMPs have demonstrated potential in modulating immune responses and controlling inflammation.

Purpose of the Study:

  • To review the scientific literature on the anti-inflammatory mechanisms of AMPs in various immune cells.
  • To elucidate the immunomodulatory characteristics of AMPs, including their effects on immune cell activation, differentiation, and inflammatory mediators.
  • To provide a comprehensive understanding of AMPs' role in immune system regulation for potential therapeutic applications in inflammatory diseases.

Main Methods:

  • Literature review of scientific studies on AMPs and their anti-inflammatory effects.
  • Analysis of evidence for AMP mechanisms in immune cells such as macrophages, monocytes, lymphocytes, mast cells, dendritic cells, neutrophils, and eosinophils.
  • Synthesis of data on AMP-induced changes in inflammatory mediators and signaling pathways.

Main Results:

  • AMPs exhibit diverse anti-inflammatory mechanisms across multiple immune cell types.
  • AMPs can activate and differentiate immune cells, influencing the production of inflammatory mediators.
  • AMPs regulate cellular functions and signaling pathways involved in inflammation.

Conclusions:

  • AMPs possess significant anti-inflammatory and immunomodulatory properties.
  • Understanding AMP mechanisms in immune cells is crucial for developing novel anti-inflammatory therapies.
  • AMPs represent a potential therapeutic strategy for treating various inflammatory conditions.
Keywords:
anti-inflammatoryantimicrobial peptidesimmune cellimmunomodulatoryinflammatory mediatorssignaling pathways

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