Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Injectable Biopolymer Hydrogel Complex (PN/HA/B3) for Facial Skin Redensification and General Rejuvenation: Clinical Report on Device Safety and Efficacy.

Journal of functional biomaterials·2026
Same author

Adhesive hydrogel-enabled integrative fixation for cartilage and osteochondral repair.

Frontiers in bioengineering and biotechnology·2026
Same author

In Vitro Evaluation of an Adhesive Hydrogel-Based Chondrocyte Carrier for Enhanced Therapeutic Delivery.

Macromolecular bioscience·2026
Same author

Advances in Medicalized Hair Loss Solutions: A Review of Current Clinical Practices and Regenerative Medicine-Based Protocols with Focus on Off-Label Injectable Treatments.

Journal of clinical medicine·2026
Same author

Non-Crosslinked Hyaluronic Acid Redensity 1<sup>®</sup> Supports Cell Viability, Proliferation, and Collagen Deposition in Early Burn Management.

Pharmaceutics·2026
Same author

[Knee dislocation : an acute multisystem failure].

Revue medicale suisse·2025

Related Experiment Video

Updated: Jul 15, 2025

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

17.5K

Autologous and Allogeneic Cytotherapies for Large Knee (Osteo)Chondral Defects: Manufacturing Process Benchmarking

Virginie Philippe1,2, Annick Jeannerat3, Cédric Peneveyre3

  • 1Orthopedics and Traumatology Service, Lausanne University Hospital, University of Lausanne, CH-1011 Lausanne, Switzerland.

Pharmaceutics
|September 28, 2023
PubMed
Summary

This study compares autologous chondrocyte implantation (ACI) with allogeneic cell therapy for knee cartilage repair. Allogeneic grafts showed comparable quality and functionality, offering advantages in standardization and logistics for future clinical use.

Keywords:
FE002 primary chondroprogenitorsallogeneic cytotherapiesautologous chondrocyte implantationcartilage defectcell therapychondrogenesismanufacturing processstandardized transplant producttissue engineeringtranslational research

More Related Videos

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
08:58

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

14.4K
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

10.4K

Related Experiment Videos

Last Updated: Jul 15, 2025

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

17.5K
Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
08:58

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

14.4K
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

10.4K

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Large knee osteochondral defects often require cytotherapies for management.
  • Autologous chondrocyte implantation (ACI) is a 30-year-old clinical standard.
  • Allogeneic cell therapy using FE002 primary chondroprogenitors is under investigation.

Purpose of the Study:

  • To comparatively assess autologous and allogeneic cell-based knee chondrotherapies.
  • Evaluate quality, safety, and functional attributes for clinical development.
  • Benchmark manufacturing processes and control strategies.

Main Methods:

  • Protocol benchmarking for manufacturing and control.
  • Safety analyses of allogeneic FE002 cellular active substance.
  • Validation of autologous and allogeneic bioengineered grafts.

Main Results:

  • Autologous grafts showed significant chondrogenic induction (COL2, ACAN upregulation, ECM synthesis).
  • Allogeneic grafts demonstrated comparable endpoint quality and functionality.
  • Allogeneic approach offers reduced cellular variability and enhanced process standardization.

Conclusions:

  • Allogeneic FE002 cell-bearing grafts present key advantages for orthopedic protocols.
  • Validated translational parameters support allogeneic cell therapy development.
  • Study sets a standard for future allogeneic progenitor cell-based clinical investigations.