Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Theranostic Nanoparticles for Fluorosensitive Visualization and Inhibition of Amyloid Beta-Induced Neuroinflammation.

Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems·2026

Same author

Harnessing Targeted Polymerized Salicylic Acid Particles to Mitigate Neutrophil-Driven Inflammation.

ACS biomaterials science & engineering·2026

Same author

Discovery and Development of One Monomer Molecularly Imprinted Polymers (OMNiMIPs).

Polymers·2025

Same author

Analytical Perspectives in the Study of Polyvalent Interactions of Free and Surface-Bound Oligonucleotides and Their Implications in Affinity Biosensing.

International journal of molecular sciences·2023

Search research articles

Related Experiment Video

Updated: Jul 15, 2025

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

Benzylfentanyl as a Surrogate Template for Fentanyl-Selective Imprinted Polymers.

Md Ragib Hasan¹, David A Spivak¹

¹Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.

|September 28, 2023

Summary

Researchers developed a novel molecularly imprinted polymer (MIP) for detecting fentanyl. This new method offers a cost-effective and portable alternative to current expensive and complex fentanyl detection techniques.

Keywords:

benzylfentanyl fentanyl molecular recognition molecularly imprinted polymer (MIP)narcotics

More Related Videos

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB

Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB

Published on: June 28, 2011

Related Experiment Videos

Last Updated: Jul 15, 2025

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB

Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB

Published on: June 28, 2011

Area of Science:

Analytical Chemistry
Materials Science
Forensic Science

Background:

Illicit fentanyl use causes numerous global opioid-related deaths.
Current fentanyl detection methods are costly, slow, require special storage, and use complex, unportable equipment.
There is a need for rapid, portable, and affordable fentanyl detection solutions.

Purpose of the Study:

To develop a molecularly imprinted polymer (MIP) for selective fentanyl detection.
To create a recognition element for handheld sensors or simple assay formats.
To provide a viable alternative to existing complex fentanyl detection technologies.

Main Methods:

A molecularly imprinted polymer was synthesized using methacrylic acid (MAA) and ethyleneglycol dimethacrylate (EGDMA) with benzylfentanyl (Bfen) as the template.
The optimal ratio of template to functional monomer was determined.
Selectivity of the Bfen-MIP for fentanyl and its template was evaluated against common narcotics using High-Performance Liquid Chromatography (HPLC).

Main Results:

The synthesized Bfen-MIP demonstrated successful selective binding of the benzylfentanyl template.
The Bfen-MIP showed selective binding for actual fentanyl.
The polymer exhibited superior selectivity for fentanyl compared to other common narcotics like methamphetamine, cocaine, and heroin.

Conclusions:

Molecularly imprinted polymers offer a promising approach for developing simple and portable fentanyl detection tools.
The Bfen-MIP exhibits high selectivity for fentanyl, making it suitable for rapid detection applications.
This MIP-based strategy could significantly improve law enforcement and public safety capabilities in combating the opioid crisis.