Jove
Visualize
Contact Us

Related Concept Videos

Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

2.7K
Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
2.7K
Bone Remodeling01:40

Bone Remodeling

38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Assessment of the Microbiological and Histopathological Picture of the Implantation Zone of a Nanocellulose-based Biocomposite <i>In Vivo</i>.

In vivo (Athens, Greece)·2026
Same author

Enhancing Gypsum Plaster with Encapsulated Fischer-Tropsch Paraffin Wax as a Phase-Change Additive for Broad-Range Thermal Energy Storage.

Polymers·2026
Same author

Management of Iatrogenic Hallux Varus with Local Soft Tissue Reconstruction: A Case Series with Mid-Term Outcomes.

Orthopedic reviews·2026
Same author

Pre-Exposure Behavioral and Physiological Markers Predict Future Alcohol Consumption Under Free Choice in Rhesus Monkeys.

Journal of studies on alcohol and drugs·2026
Same author

Low-temperature <i>Versus</i> High-temperature Sintering: Regenerative and Osteoimmunological Insights from Bio-Oss<sup>®</sup>, Ti-Oss<sup>®</sup> in Sinus Lift Surgery.

In vivo (Athens, Greece)·2026
Same author

Observation of Direct and Indirect Effects of Surface Stabilizer on the Attenuation Coefficient of CdTe Nanoplatelet Films.

Nanomaterials (Basel, Switzerland)·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 15, 2025

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

7.6K

Composite Bone Cements with Enhanced Drug Elution.

Kirill Cherednichenko1, Adeliya Sayfutdinova1, Denis Rimashevskiy1,2

  • 1Department of Physical and Colloid Chemistry, Faculty of Chemical and Environmental Engineering, National University of Oil and Gas "Gubkin University", Moscow 119991, Russia.

Polymers
|September 28, 2023
PubMed
Summary

Natural additives like nanofibrillated cellulose enhance antibiotic-loaded bone cement (ALBC) for orthopedic surgery. These composites improve drug elution and mechanical strength, offering better infection control and treatment options.

Keywords:
ALBCNFCPMMAantibiotic releasebone cementnanocellulosevancomycin

More Related Videos

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

1.9K
Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
12:27

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

7.7K

Related Experiment Videos

Last Updated: Jul 15, 2025

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

7.6K
Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

1.9K
Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
12:27

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

7.7K

Area of Science:

  • Orthopedic Biomaterials
  • Polymer Science
  • Drug Delivery Systems

Background:

  • Antibiotic-loaded bone cement (ALBC) is crucial for orthopedic infection prophylaxis and treatment.
  • Adding antibiotics to bone cement can reduce mechanical strength and limit drug elution.
  • Natural micro/nanoscale materials offer potential as additives to improve ALBC properties.

Purpose of the Study:

  • To investigate the effects of natural additives (halloysite, CNC, MFC, NFC) on vancomycin-loaded bone cement.
  • To evaluate the impact of these additives on polymerization characteristics and mechanical properties.
  • To determine the optimal additive for enhanced drug release and cement performance.

Main Methods:

  • Commercial Simplex P bone cement preloaded with vancomycin was used.
  • Four natural additives (halloysite, nanocrystalline cellulose, micro- and nanofibrillated cellulose) were incorporated.
  • Polymerization (temperature, setting time, monomer leaching), drug elution, and microhardness were comprehensively studied.

Main Results:

  • All natural additives enhanced drug elution and microhardness compared to standard ALBC.
  • Nanofibrillated cellulose (NFC) demonstrated the best overall performance.
  • NFC improved polymerization rate, reduced monomer leaching, and increased antibiotic release and microhardness.

Conclusions:

  • Natural micro/nanoscale materials can significantly improve the properties of antibiotic-loaded bone cement.
  • Nanofibrillated cellulose is a promising additive for developing advanced bone cements with superior drug delivery and mechanical integrity.
  • These enhanced ALBC formulations hold potential for improved orthopedic infection management.