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Mouse Models of Mayaro Virus.

Rafael Borges Rosa1,2, Emilene Ferreira de Castro3,4, Débora de Oliveira Santos4

  • 1Department of Virology and Experimental Therapy (LAVITE), Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), Recife 50740-465, Brazil.

Viruses
|September 28, 2023
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Summary

Mayaro virus (MAYV) causes severe Mayaro fever. This review explores how mouse models are crucial for understanding MAYV pathogenesis and developing new treatments and vaccines.

Keywords:
Mayaroanimal modeldrugs and vaccinespublic health

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Area of Science:

  • Virology
  • Infectious Diseases
  • Animal Models

Background:

  • Mayaro virus (MAYV) causes Mayaro fever, characterized by severe myalgia and arthralgia, posing a public health concern.
  • Emerging viral threats necessitate robust in vivo models for disease research and countermeasure development.

Purpose of the Study:

  • To review existing studies utilizing mice as an experimental model for Mayaro virus.
  • To discuss the contribution of mouse models to understanding MAYV pathogenesis.
  • To highlight the role of mouse models in developing Mayaro fever therapeutics and vaccines.

Main Methods:

  • Literature review of studies involving Mayaro virus and mouse models.
  • Analysis of Mayaro virus pathogenesis in different mouse strains.
  • Evaluation of mouse model suitability for Mayaro fever research.

Main Results:

  • Mice effectively recapitulate key aspects of Mayaro fever observed in humans.
  • Various mouse strains have been investigated, offering insights into differential responses to MAYV infection.
  • Mouse models are instrumental in preclinical studies for Mayaro fever drugs and vaccines.

Conclusions:

  • Mouse models are essential for advancing the understanding of Mayaro virus pathogenesis.
  • Continued research using mouse models will accelerate the development of effective Mayaro fever treatments and vaccines.
  • Mice serve as a valuable platform for Mayaro virus research, aiding public health efforts.