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Mouse Models of Mayaro Virus
Rafael Borges Rosa1,2, Emilene Ferreira de Castro3,4, Débora de Oliveira Santos4
1Department of Virology and Experimental Therapy (LAVITE), Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), Recife 50740-465, Brazil.
Abstract:
Mayaro virus (MAYV), the etiologic agent of Mayaro fever, leads patients to severe myalgia and arthralgia, which can have a major impact on public health in all the countries where the virus circulates. The emergence and dissemination of new viruses have led the scientific community to develop new in vivo models that can help in the fight against new diseases. So far, mice have been the most used animal model in studies with MAYV and have proved to be an adequate model for recapitulating several aspects of the disease observed in humans. Mice are widely used in in vivo research and, therefore, are well known in the scientific community, which has allowed for different strains to be investigated in the study of MAYV. In this review, we summarize the main studies with MAYV using mice as an experimental model and discuss how they can contribute to the advancement of the understanding of its pathogenesis and the development of new drugs and vaccines.
Insights
Mayaro virus (MAYV) causes severe Mayaro fever. This review explores how mouse models are crucial for understanding MAYV pathogenesis and developing new treatments and vaccines.
Area of Science:
- Virology
- Infectious Diseases
- Animal Models
Background:
- Mayaro virus (MAYV) causes Mayaro fever, characterized by severe myalgia and arthralgia, posing a public health concern.
- Emerging viral threats necessitate robust in vivo models for disease research and countermeasure development.
Purpose of the Study:
- To review existing studies utilizing mice as an experimental model for Mayaro virus.
- To discuss the contribution of mouse models to understanding MAYV pathogenesis.
- To highlight the role of mouse models in developing Mayaro fever therapeutics and vaccines.
Main Methods:
- Literature review of studies involving Mayaro virus and mouse models.
- Analysis of Mayaro virus pathogenesis in different mouse strains.
- Evaluation of mouse model suitability for Mayaro fever research.
Main Results:
- Mice effectively recapitulate key aspects of Mayaro fever observed in humans.
- Various mouse strains have been investigated, offering insights into differential responses to MAYV infection.
- Mouse models are instrumental in preclinical studies for Mayaro fever drugs and vaccines.
Conclusions:
- Mouse models are essential for advancing the understanding of Mayaro virus pathogenesis.
- Continued research using mouse models will accelerate the development of effective Mayaro fever treatments and vaccines.
- Mice serve as a valuable platform for Mayaro virus research, aiding public health efforts.
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