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Molecular Prevalence and Genotype Distribution of Human Adenovirus in Iranian Children with Gastroenteritis

Abdulhussain Kadhim Jwaziri1, Mohammad Hadi Karbalaie Niya2, Pegah Khales3

  • 1Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Fetal and Pediatric Pathology
|September 28, 2023
PubMed

Insights

Human adenovirus (HAdV) was detected in 15% of young Iranian children with gastroenteritis. Types 2 and 41 were identified, suggesting HAdV type 2 contributes to childhood gastroenteritis.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Gastroenteritis is a common illness in children worldwide.
  • Human adenovirus (HAdV) is a known cause of gastroenteritis in pediatric populations.
  • Limited data exists on HAdV prevalence and genotypes in Iranian children.

Purpose of the Study:

  • To determine the molecular prevalence of HAdV in children under five with gastroenteritis in Iran.
  • To identify the genotype distribution of HAdV in this cohort.

Main Methods:

  • One hundred stool samples from hospitalized children with gastroenteritis were collected.
  • Polymerase chain reaction (PCR) was used to detect HAdV DNA.
  • Positive samples were sequenced for genotyping.

Main Results:

  • HAdV DNA was detected in 15% of the samples.
  • Prevalence was highest in children aged 24-60 months (40%) and lowest in those aged 7-12 months (13.3%).
  • Sequencing identified HAdV types 2 (4 isolates) and 41 (5 isolates).

Conclusions:

  • HAdV is a significant cause of gastroenteritis in young children in Iran.
  • HAdV type 2, alongside types 40 and 41, should be considered in the etiology of childhood gastroenteritis.
  • Further research on HAdV epidemiology in Iran is warranted.
Abstract

Keywords:
Adenoviruschildrendiarrheagastroenteritismolecular prevalence

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