Related Experiment Video

Updated: Jul 15, 2025

Magnetic-Activated Cell Sorting Strategies to Isolate and Purify Synovial Fluid-Derived Mesenchymal Stem Cells from a Rabbit Model
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Magnetic-Activated Cell Sorting Strategies to Isolate and Purify Synovial Fluid-Derived Mesenchymal Stem Cells from a Rabbit Model

Published on: August 10, 2018

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Rejuvenation of Senescent Mesenchymal Stem Cells to Prevent Age-Related Changes in Synovial Joints

Tatiana Sekelova1,2, Lubos Danisovic1,2, Michaela Cehakova1,2

  • 1National Institute of Rheumatic Diseases, Piestany, Slovakia.

Cell Transplantation
|September 28, 2023
PubMed

Insights

Aging diminishes the regenerative capacity of mesenchymal stem cells (MSCs), impacting therapies. This review explores senescent MSCs (sMSCs) and rejuvenation strategies for joint aging.

Area of Science:

  • Cellular biology
  • Regenerative medicine
  • Gerontology

Background:

  • Mesenchymal stem cells (MSCs) possess regenerative potential but decline with age.
  • Cellular senescence, particularly in synovial MSCs, contributes to age-related joint diseases like osteoarthritis.
  • Senescent MSCs (sMSCs) exhibit altered self-renewal, differentiation, and secrete detrimental factors (senescence-messaging secretome).

Purpose of the Study:

  • To review the characteristics of senescent MSCs (sMSCs).
  • To elucidate the role of sMSCs in cartilage and synovial joint aging.
  • To discuss current rejuvenation strategies for age-related pathological changes in MSCs.

Main Methods:

  • Literature review focusing on cellular senescence in MSCs.
  • Analysis of factors regulating the senescent phenotype in MSCs.
  • Inclusion of evidence from in vivo experiments.

Main Results:

  • Aging impairs MSC biological activity, posing challenges for regenerative therapies.
  • Senescent MSCs contribute to the aging of cartilage and synovial joints.
  • The senescence-messaging secretome of sMSCs has adverse effects.

Conclusions:

  • Understanding sMSC characteristics is crucial for addressing age-related joint degeneration.
  • Rejuvenation approaches offer potential to delay or reverse MSC aging.
  • Further research into MSC senescence and rejuvenation is warranted for therapeutic advancements.
Keywords:
aging jointrejuvenationsenescencesenescence-messaging secretomesenescent mesenchymal/medicinal stem/signaling cells

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