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Published on: December 21, 2014
The multifaceted roles of matrix metalloproteinases in lung cancer
1Department of Emergency, The Third Hospital of Changsha, Changsha, China.
Background:
Though the matrix metalloproteinases (MMPs) are widely investigated in lung cancer (LC), however, almost no review systematically clarify their multi-faced roles in LC.
Methods:
We investigated the expression of MMPs and their effects on survival of patients with LC, the resistance mechanisms of MMPs in anti-tumor therapy, the regulatory networks of MMPs involved, the function of MMPs inducing CSCLs, MMPs-related tumor immunity, and effects of MMP polymorphisms on risk of LC.
Results:
High expression of MMPs was mainly related to poor survival, high clinical stages and cancer metastasis. Role of MMPs in LC are multi-faced. MMPs are involved in drug resistance, induced CSCLs, participated in tumor immunity. Besides, MMPs polymorphisms may increase risk of LC.
Conclusions:
MMPs might be promising targets to restore the anti-tumor immune response and enhance the killing function of nature immune cells in LC.
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