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C-reactive protein in population samples.

T Palosuo, T Husman, J Koistinen

    Acta Medica Scandinavica
    |January 1, 1986
    PubMed
    Summary
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    C-reactive protein (CRP) is elevated in a small percentage of healthy donors but more common in the general population, often linked to infections or smoking. Elevated CRP was rarely found in pre-illness samples from rheumatoid arthritis patients.

    Area of Science:

    • Biochemistry
    • Immunology
    • Clinical Chemistry

    Background:

    • C-reactive protein (CRP) is a key inflammatory marker.
    • Understanding CRP levels in various populations is crucial for diagnostics.
    • Previous studies have explored CRP in relation to rheumatoid arthritis and other conditions.

    Purpose of the Study:

    • To investigate the prevalence and significance of elevated C-reactive protein (CRP) levels in different human specimen sets.
    • To assess the association of raised CRP with acute respiratory infections, smoking, and rheumatoid arthritis.
    • To evaluate CRP levels in pre-illness sera of individuals who later developed rheumatoid arthritis.

    Main Methods:

    • Analysis of CRP levels in three distinct specimen groups: healthy blood donors, a general middle-aged population sample, and pre-illness sera from future rheumatoid arthritis patients.

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  • CRP levels were quantified, with a threshold of >10 mg/l considered raised.
  • Correlation of elevated CRP with clinical factors like infections, smoking, and diagnosed rheumatoid arthritis.

    • Main Results:

    • Raised CRP levels (>10 mg/l) were found in 2.0% of healthy donors and 6.6% of a middle-aged population sample.
    • Acute respiratory infections (over 40%) and smoking (about 20%) were associated with elevated CRP in the population sample.
    • Rheumatoid arthritis was present in 14% of individuals with elevated CRP in the population sample, but only one pre-illness serum specimen showed increased CRP.

    Conclusions:

    • Elevated CRP is more prevalent in the general population than in healthy donors, often linked to transient conditions like infections or lifestyle factors such as smoking.
    • While some individuals with elevated CRP have rheumatoid arthritis, CRP is not consistently elevated in the pre-illness phase of this autoimmune disease.
    • CRP's utility as a predictive marker for rheumatoid arthritis development appears limited based on this study.