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Excessive hypercalcaemia and mixed connective tissue disease.

P D Christensen, H Starklint, M Tvede

Acta Medica Scandinavica

|January 1, 1986

Summary

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A young woman with severe hypercalcemia achieved normal calcium levels after treatment but later died from complications including organ failure. The cause of death was unclear, but mixed connective tissue disease was diagnosed.

Area of Science:

Endocrinology
Immunology
Oncology

Background:

Extreme hypercalcemia in a young patient presented a diagnostic and therapeutic challenge.
Standard treatments including calcitonin, mitramycin, and parathyroidectomy were employed to manage hypercalcemia.

Observation:

Normocalcemia was achieved within four weeks of treatment.
Despite achieving normocalcemia, the patient experienced cutaneous necrosis, impaired circulation, and multiple organ failure, leading to death.
Serum parathyroid hormone levels and parathyroid tissue were normal, ruling out primary hyperparathyroidism.

Findings:

Mixed connective tissue disease was diagnosed based on specific autoantibody profiles.
The potential roles of Clostridium difficile toxin and an acinic cell tumor in the patient's demise remain undetermined.

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Implications:

This case highlights the complex interplay between endocrine disorders, autoimmune diseases, and potential complications.
The unexplained etiology of the patient's death underscores the need for further investigation into rare disease presentations and treatment outcomes.