Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Association of Hypertension Based on Systolic and Diastolic Blood Pressure (SBP and DBP) With Dental Visits in the Population Aged 45 and Older: Cross-Section Study Results From the China Health and Retirement Longitudinal Study (CHARLS).

Clinical cardiology·2026
Same author

The Effects of Different Organic Amendment Strategies on Soil Properties and Microbial Communities in Maize Monocropping.

Plants (Basel, Switzerland)·2026
Same author

In vitro analysis of a glass solder matrix on ATZ-ceramic-samples using human dental pulp cells and L929 mouse fibroblasts.

International journal of implant dentistry·2026
Same author

Demographic variation of styloid process morphology in panoramic radiography.

BMC oral health·2026
Same author

Effect of ADSCs-Exos on Pg-LPS-Induced Osteoclastogenesis in an In Vitro Inflammatory Model.

Oral diseases·2026
Same author

Ossification of Mandibular Central Giant Cell Granuloma (CGCG) in Neurofibromatosis Type 1 Patients.

Cancer diagnosis & prognosis·2026

Related Experiment Video

Updated: Jul 15, 2025

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
05:28

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

2.2K

Correlations between gut microbiota and lichen planus: a two-sample Mendelian randomization study.

Ming Yan1,2, Yu-Long Ouyang1, Li-Yuan Xiao1

  • 1Department of Oral and Maxillofacial Surgery, Guiyang Hospital of Stomatology, Guiyang, China.

Frontiers in Immunology
|September 28, 2023
PubMed
Summary

Gut microbiota influences lichen planus (LP) risk. Certain bacteria like Oxalobacteraceae may protect against LP, while others like Desulfovibrio are linked to its onset, supporting the intestine-skin axis theory.

Keywords:
Mendelian randomization studycorrelationsgut microbiotaintestine-skin axislichen planus

More Related Videos

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.3K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.2K

Related Experiment Videos

Last Updated: Jul 15, 2025

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
05:28

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

2.2K
A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.3K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

28.2K

Area of Science:

  • Microbiology
  • Immunodermatology
  • Genetics

Background:

  • Lichen planus (LP) occurrence is increasingly linked to gut microbiota composition.
  • Understanding the gut-LP axis is crucial for novel therapeutic strategies.

Purpose of the Study:

  • To investigate the causal relationship between specific gut microbiota and the risk of developing lichen planus (LP).
  • To identify bacterial genera with protective or detrimental effects on LP initiation.

Main Methods:

  • Employed a two-sample Mendelian randomization (MR) method.
  • Utilized single nucleotide polymorphisms (SNPs) associated with gut microbiota as instrumental variables (IVs).
  • Applied inverse-variance weighted (IVW) analysis for causal inference.

Main Results:

  • Identified six bacterial genera significantly associated with LP risk.
  • Oxalobacteraceae, Victivallaceae, and Actinobacteria showed protective effects, potentially restraining LP initiation.
  • Desulfovibrio, Veillonella, and Ruminococcus gauvreauii groups were causally correlated with LP onset.

Conclusions:

  • The gut microbiota-LP relationship is complex, not strictly positive or negative.
  • Findings support the intestine-skin axis theory, highlighting microbial influence on skin conditions.
  • Further research is needed to elucidate the precise mechanisms of microbial action on skin and confirm protective roles.