Lymphadenitis caused by Purpureocillium lilacinum in a patient with CARD9 deficiency
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Updated: Jul 15, 2025

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
Published on: June 26, 2018
Hidetaka Majima1, Yuzaburo Inoue2, Yuichiro Otsuka3
1Division of Clinical Research, Medical Mycology Research Center, Chiba University, Chiba, Japan.
Abstract:
We hereby make the first report of a case of mycosis caused by Purpureocillium lilacinum in CARD9 deficiency. A 40-year-old woman complained of lymph node swellings in the left cervical area. She also had chronic mucocutaneous candidiasis (CMC), and was found to have CARD9 deficiency. Lymphadenitis by P. lilacinum was confirmed. The diagnosis was difficult, as culturing the biopsy specimen at a cautiously selected temperature (25 °C) and genetic analysis were both required. Oral administration of voriconazole improved her lymphadenopathy.
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