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Personalized clinical managements through exploring circulating neural cells and electroencephalography
Parvin Mehdipour1, Nima Fathi2, Masoud Nosratabadi3
1Department of Medical Genetics, Tehran University of Medical Sciences, Tehran 14176-1315, Iran. mehdipor@tums.ac.ir.
World Journal of Experimental Medicine
|September 28, 2023
Summary
Early detection of Alzheimer disease (AD) is improved by analyzing protein expression of Ets2 in circulating neural cells. This approach enables a personalized, predictive, preventive, and protective (5xP) management strategy for AD patients and at-risk relatives.
Area of Science:
- Neurogenetics
- Cell Biology
- Personalized Medicine
Background:
- Alzheimer disease (AD) diagnosis lacked early detection methods for 116 years.
- Up-regulation of Ets2 enhances neuronal susceptibility and degeneration in AD.
- Protein expression (PE) of Ets2 significantly impacts AD and Down's syndrome pathogenesis.
Purpose of the Study:
- To integrate cell biology into neuro-genetics for a 5xP (personalized, prognostics, predictive, preventive, predisposing) platform.
- To stratify brain channel behavior in AD patients before and after light music intervention.
- To develop early detection and personalized management strategies for AD.
Main Methods:
- Exploration of protein expression (PE) assays and electroencephalography of brain channels.
- Application of a triangle style using cellular networks and manual/flow-cytometry based PE assay of Ets2 in peripheral blood.
- Inclusion of genetic counseling, pedigree analysis, psychological status, environmental factors, genetic analysis, and complementary tests.
Main Results:
- PE of Ets2 plays a pathogenic role in AD, revealing heterogeneity and evolutionary course.
- Ets2 analysis, alongside polymorphisms in ATM, VEGF, and EGF, identified distinct cellular behaviors.
- An early detection platform was highlighted using circulating neural cells (CNCs) and molecular investigation for individuals predisposed to AD or brain neoplasia.
Conclusions:
- Application of single CNCs and brain channel ratios provides a 5xP personalized clinical management model for early AD detection and therapy.
- Novel findings in brain channels offer personalized markers for health and disease management.
- This approach facilitates early detection and personalized therapy for AD patients and predisposed relatives.
