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[New effects of a topical antimicrobial (agent) in the treatment of acute tonsillopharyngitis]
A Yu Ovchinnikov1, N A Miroshnichenko1, Yu O Nikolaeva1
1Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
Abstract:
Sore throat is the leading symptom of acute tonsillopharyngitis associated with previous acute respiratory viral infections, including COVID-19. The pathogenesis of these nosologies is based on the cumulative result of the primary direct damaging effect of viruses and secondary alternative inflammatory changes in the mucosal epithelium in the focus of infection, which, against the background of changes in the functions of the regional microbiota, leads to the development of viral-bacterial inflammation that goes beyond the protective-reparative level. In the treatment of acute tonsillopharyngitis after exclusion of GABHS etiology, topical etiotropic drugs are often used. It is desirable to achieve a uniform distribution of active ingredients, and to maximize the use of additional pharmacological capabilities (irrigation-eliminative action, reparative effect). To build up the evidence base for the effectiveness of just such medicines on the basis of the Department of Otorhinolaryngology of the Moscow State Medical University named after. A.I. Evdokimov, an observational prospective comparative study was conducted, using, in addition to the clinical assessment method, cytomorphological approaches (cytomorphometry). The results of the study demonstrated that gargling with a solution of hydroxymethylquinoxylindioxide (Dioxydin 0.25 mg/ml solution for topical application) in adult patients with acute tonsillopharyngitis provides rapid relief of pain, a decrease in the severity of inflammation symptoms, and also makes it possible to achieve limitation of the degree of destruction of the epithelium in the height of inflammation and a more complete and rapid recovery of the damaged mucous membrane by the time of recovery.
Insights
Gargling with Dioxydin (hydroxymethylquinoxylindioxide) effectively relieves sore throat pain and reduces inflammation in acute tonsillopharyngitis. This treatment also aids in limiting epithelial damage and promotes faster mucosal recovery.
Area of Science:
- Otorhinolaryngology
- Infectious Diseases
- Pharmacology
Background:
- Acute tonsillopharyngitis, often following viral infections like COVID-19, presents with sore throat due to viral damage and secondary bacterial inflammation.
- Current treatments for acute tonsillopharyngitis (excluding Group A Streptococcus) often involve topical agents, with a need for uniform distribution and additional therapeutic actions like irrigation and repair.
- Understanding the pathogenesis of viral-bacterial inflammation and its impact on mucosal epithelium is crucial for effective treatment strategies.
Purpose of the Study:
- To evaluate the effectiveness of Dioxydin (0.25 mg/ml solution) gargle in adult patients with acute tonsillopharyngitis.
- To assess the impact of Dioxydin on pain relief, inflammation severity, epithelial damage, and mucosal recovery.
- To build evidence for topical etiotropic drugs with irrigation-eliminative and reparative actions in treating acute tonsillopharyngitis.
Main Methods:
- An observational prospective comparative study was conducted at the Department of Otorhinolaryngology, Moscow State Medical University.
- Clinical assessment methods were employed alongside cytomorphological approaches, specifically cytomorphometry, for detailed analysis.
- Adult patients with acute tonsillopharyngitis (GABHS etiology excluded) were treated with Dioxydin gargle.
Main Results:
- Gargling with Dioxydin provided rapid relief of sore throat pain.
- A significant decrease in the severity of inflammation symptoms was observed.
- The study demonstrated limitation of epithelial destruction and facilitated more complete and rapid recovery of the damaged mucous membrane.
Conclusions:
- Dioxydin (0.25 mg/ml solution) is an effective topical treatment for acute tonsillopharyngitis in adults.
- The therapeutic benefits include rapid pain relief, reduced inflammation, and enhanced mucosal healing.
- Dioxydin offers valuable pharmacological capabilities, including irrigation-eliminative and reparative effects, for managing acute tonsillopharyngitis.
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