On the interrelations of immune and mediator receptors of mice lymphocytes

It was shown that the blockade of M-cholinereceptors, of B-lymphocytes in the spleen of mice of the BALB/c line immune to sheep erythrocytes, by parasympatholytics 3H-Quinuclidinyl benzilate, etc., markedly inhibits the rosette-formation with the specific antigen. The blockade of M-cholinereceptors of B-lymphocytes in the mice spleen of the given line by the anticholinereceptor rabbit serum (with removed Forsmann antibodies) induces a similar result. The specific antigen fixation on B-lymphocytes of mice immunized by egg albumin is suppressed by preliminary blockade of M-cholinereceptors by the above mentioned parasympatholytics. The number of free cholinereceptors on the surface of B-lymphocytes of mice spleen immunized with egg albumin, was reduced after the specific antigen was joined. The blockade of beta-adrenoreceptors of mice spleen evokes a similar effect but in a lesser degree. The problem of interrelation of immune and mediator lymphocyte receptors is discussed in relation with the mechanisms of nervous regulation of immune and allergic reactions.