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Ida-Marie Tp Arendt1,2,3, Stine Bjerrum Møller1,2

  • 1Afdeling for Traume- og Torturoverlevere, ATT, Psykiatrien i Region Syddanmark.

Ugeskrift for Laeger
|September 28, 2023
PubMed
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Difficult-to-treat depression (DTD) patients show higher psychopathological complexity and respond less effectively to psychotherapy. Promising treatments like schema therapy require further study for better patient care.

Area of Science:

  • Psychiatry and Psychology
  • Clinical Neuroscience

Background:

  • A significant patient subgroup (15-35%) experiences difficult-to-treat depression (DTD), presenting unique psychopathological complexities.
  • These patients often exhibit differential responses to standard treatments compared to those with non-DTD.

Approach:

  • This review synthesizes current understanding of psychotherapy effectiveness in DTD.
  • It explores potential reasons for reduced treatment efficacy, including patient-specific characteristics.

Key Points:

  • Psychotherapy's effect is generally lower in DTD populations.
  • Specific psychotherapies, including cognitive behavioral analysis system of psychotherapy, mindfulness-based cognitive therapy, and schema therapy, show promise but need more research.
  • Recognizing DTD early is crucial for effective clinical management.

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Conclusions:

  • Tailoring treatment strategies is essential for patients with DTD.
  • Further research into specialized psychotherapies is warranted to improve outcomes for this challenging patient group.