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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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Prevalence of allergic contact dermatitis in children with and without atopic dermatitis: A multicenter retrospective

Hadley Johnson1, Marcella R Aquino2, Alan Snyder3

  • 1School of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota; Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Journal of the American Academy of Dermatology
|September 28, 2023
PubMed

Insights

Children with atopic dermatitis (AD) often have allergic contact dermatitis, which is underdiagnosed. Patch testing is crucial for identifying common allergens like bacitracin in children with AD.

Area of Science:

  • Pediatric Dermatology
  • Allergen Identification
  • Contact Dermatitis Research

Background:

  • Atopic dermatitis (AD) and allergic contact dermatitis share clinical and histological features, leading to underdiagnosis of the latter in children with AD.
  • Many children with AD are not referred for patch testing, hindering accurate diagnosis of allergic contact dermatitis.

Purpose of the Study:

  • To update prevalence data for common contact allergens in pediatric populations.
  • To compare allergen prevalence between children with and without atopic dermatitis.

Main Methods:

  • Retrospective case-control study utilizing the Pediatric Allergic Contact Dermatitis Registry.
  • Data collected from 2018 to 2022, including 912 children (615 with AD, 297 without AD).

Main Results:

  • Children with AD showed a higher likelihood of positive patch test (PPT) results, with more frequent reactions to bacitracin, carba mix, and cocamidopropyl betaine.
  • AD group had a longer dermatitis history, saw more providers, and exhibited more generalized dermatitis distribution.
  • Significantly increased prevalence of specific allergens (bacitracin, carba mix, cocamidopropyl betaine) was observed in children with AD.

Conclusions:

  • Children with atopic dermatitis are more prone to positive patch test reactions.
  • Referral for allergic contact dermatitis evaluation and patch testing is recommended for children with AD.
  • Accurate diagnosis of allergic contact dermatitis is essential for effective management in pediatric patients.
Abstract

Keywords:
allergic contact dermatitisatopic dermatitischildrenpatch testingpediatric

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