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Endogenous Regeneration of Alveolar Bone by Decellularized Tooth Matrix
A V Latyshev1, T I Danilova1, A V Kuznetsova1,2
1A. I. Yevdokimov Moscow State University of Medicine and Dentistry c caйтa, Ministry of Health of the Russian Federation, Moscow, Russia.
Bulletin of Experimental Biology and Medicine
|September 28, 2023
Summary
Decellularized tooth matrix effectively regenerates bone tissue in rat jaw defects. This biomaterial shows promise for cell-free tissue engineering in dental and maxillofacial surgery.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Oral and Maxillofacial Surgery
Background:
- Alveolar bone defects pose challenges in dental and maxillofacial surgery.
- Current bone graft substitutes have limitations in efficacy and application.
Purpose of the Study:
- To compare the bone regeneration potential of decellularized tooth matrix (DTM), demineralized tooth matrix (DTM), and Bio-Oss Spongiosa.
- To evaluate DTM as a cell-free biomaterial for alveolar bone restoration.
Main Methods:
- Critical-size alveolar bone defects were created in Wistar rats.
- Histological, histomorphometrical, and immunohistochemical analyses were performed at 30 and 60 days.
- Comparison of DTM, demineralized matrix, and Bio-Oss Spongiosa for bone healing.
Main Results:
- Decellularized tooth matrix significantly induced new bone formation by day 60.
- Demineralized matrix and Bio-Oss Spongiosa showed less regenerative capacity compared to DTM.
- DTM demonstrated effective bone tissue regeneration in the defect model.
Conclusions:
- Decellularized tooth matrix is a promising biomaterial for alveolar bone regeneration.
- DTM supports cell-free tissue engineering approaches for dental and maxillofacial applications.
- DTM offers a viable alternative for restoring bone defects in dentistry.
