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Human Leukocyte Antigen Signatures as Pathophysiological Discriminants of Microscopic Colitis Subtypes
Tenghao Zheng1,2,3, Giulia Roda4, Yamile Zabana5,6
1School of Biological Sciences, Monash University, Clayton, VIC, Australia.
Journal of Crohn'S & Colitis
|September 28, 2023
Summary
Genetic analysis reveals distinct causes for collagenous colitis (CC) and lymphocytic colitis (LC). Human leukocyte antigen (HLA) plays a key role in CC, but not LC, suggesting they are separate conditions.
Area of Science:
- Gastroenterology
- Genetics
- Immunology
Background:
- Microscopic colitis (MC) encompasses collagenous colitis (CC) and lymphocytic colitis (LC), but their distinct pathophysiological bases remain unclear.
- Genetic studies are crucial for understanding the separate mechanisms underlying CC and LC.
Conclusions:
- The findings suggest that CC and LC have distinct pathophysiological mechanisms.
- The significant predisposing role of HLA in CC, but not LC, challenges the current classification of MC as a single entity.
- A re-evaluation of the umbrella term 'microscopic colitis' may be warranted.
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