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Comment on: Relative efficacy of intracameral moxifloxacin injection methods

Stephen S Khachikian1, Marlee E Jones

  • 1From the Black Hills Regional Eye Institute, Rapid City, South Dakota (Khachikian); University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota (Jones).

Journal of Cataract and Refractive Surgery
|September 28, 2023
PubMed
Abstract

No abstract available in PubMed .

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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