Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adaptive cytoprotection: an endoscopic study in man.

D Foschi, G L Toti, P Del Soldato

    The American Journal of Gastroenterology
    |November 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Reversible Bariatric Surgery: Is Long Gastric Partition (Bariclip) Superior to Gastric Banding?

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
    Same author

    Risk Factors for Small Bowel Obstruction After Laparoscopic Ileal Pouch-Anal Anastomosis for Inflammatory Bowel Disease: A Multivariate Analysis in Four Expert Centres in Europe.

    Journal of Crohn's & colitis·2018
    Same author

    Clinical, histomorphological and therapeutic features of the Van der Woude Syndrome: literature review and presentation of an unusual case.

    European journal of paediatric dentistry·2018
    Same author

    Tongue-tie assessment: clinical aspects and a new diode laser technique for its management.

    European journal of paediatric dentistry·2016
    Same author

    Diagnosis and Treatment of Biliary Fistulas in the Laparoscopic Era.

    Gastroenterology research and practice·2016
    Same author

    Topic: Pubic Inguinal Pain Syndrome (PIPS) - Sportsman.

    Hernia : the journal of hernias and abdominal wall surgery·2015
    Same journal

    Calendar of Courses, Symposiums and Conferences.

    The American journal of gastroenterology·2026
    Same journal

    Molecular Nonendoscopic Tests for the Early Detection of Esophageal Squamous Carcinoma and High-Grade Dysplasia: Promising Progress.

    The American journal of gastroenterology·2026
    Same journal

    ACG Clinical Guideline: Colonic Diverticulitis.

    The American journal of gastroenterology·2026
    Same journal

    Continuing Medical Education Questions: July 2026.

    The American journal of gastroenterology·2026
    Same journal

    Continuing Medical Education Questions: July 2026.

    The American journal of gastroenterology·2026
    Same journal

    2026 CME Information.

    The American journal of gastroenterology·2026
    See all related articles

    Mild ethanol pre-treatment protects the duodenum from strong ethanol damage in humans. This adaptive cytoprotection, potentially mediated by prostaglandins, is blocked by acetylsalicylic acid.

    Area of Science:

    • Gastroenterology
    • Physiology

    Background:

    • The gastrointestinal tract possesses defense mechanisms against irritants.
    • Ethanol can cause damage to the duodenal mucosa.

    Purpose of the Study:

    • To investigate the protective effect of mild ethanol (20%) against strong ethanol (40%)-induced duodenal mucosal damage in humans.
    • To explore the role of adaptive cytoprotection and endogenous prostaglandins in this phenomenon.

    Main Methods:

    • Healthy volunteers underwent endoscopic examination of the duodenum.
    • Duodenal mucosa was exposed to placebo, 20% ethanol, or 40% ethanol.
    • Damage was assessed using a scoring system for hyperemia and hemorrhagic lesions.
    • The effect of acetylsalicylic acid on 20% ethanol's protective action was evaluated.

    Related Experiment Videos

    Main Results:

    • 40% ethanol caused duodenal damage (hyperemia, hemorrhagic lesions).
    • Pre-administration of 20% ethanol significantly prevented 40% ethanol-induced damage.
    • Acetylsalicylic acid abolished the protective effect of 20% ethanol.
    • 20% ethanol alone did not cause duodenal damage.

    Conclusions:

    • Adaptive cytoprotection is a physiological phenomenon in humans.
    • Mild ethanol pre-treatment confers protection against strong ethanol injury to the duodenal mucosa.
    • Endogenous prostaglandins likely play a defensive role in the gastrointestinal tract.