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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

49
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
49

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Sonodynamic therapy-based nanoplatforms for combating bacterial infections.

Pei-Yao Xu1, Ranjith Kumar Kankala1, Shi-Bin Wang1

  • 1Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, Fujian 361021, PR China; Fujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen, Fujian 361021, PR China.

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Antibiotic-resistant bacteria pose a global threat. Sonodynamic therapy (SDT) nanoplatforms offer a promising, noninvasive approach to combat these infections by leveraging ultrasound and sonosensitizers.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Infectious Diseases

Background:

  • Antibiotic resistance is a critical global health challenge, necessitating novel therapeutic strategies.
  • Sonodynamic therapy (SDT), utilizing ultrasound and sonosensitizers, presents a noninvasive method to combat bacterial infections and biofilms.
  • The development of effective sonosensitizers, whether organic molecules or inorganic nanoparticles, is crucial for SDT efficacy.

Approach:

  • This review systematically examines SDT-based antibacterial mechanisms.
  • It discusses advancements in nanoplatforms designed for sonosensitizer delivery and nanoplatforms acting as sonosensitizers.
  • The biomedical applications of multifunctional SDT-involved nanoplatforms are also explored.

Key Points:

  • Nanoplatforms are essential for loading and delivering sonosensitizers in SDT.
  • Both organic small-molecule and inorganic nanoparticle sonosensitizers are being integrated into nanoplatforms.
  • Multifunctional nanoplatforms enhance the therapeutic potential of SDT.

Conclusions:

  • Innovative SDT-based nanoplatforms show significant promise for treating bacterial infections.
  • These platforms offer a highly efficient, noninvasive therapeutic alternative to traditional antibiotics.
  • Further development of SDT nanoplatforms is expected to revolutionize the treatment of drug-resistant bacteria.