Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dissociable somatotopic representations of Chinese action verbs in the motor and premotor cortex.

Scientific reports·2013

Same author

High quantum-yield CdSexS1-x/ZnS core/shell quantum dots for warm white light-emitting diodes with good color rendering.

Nanotechnology·2013

Same author

A novel microfluidic mixer based on dual-hydrodynamic focusing for interrogating the kinetics of DNA-protein interaction.

The Analyst·2013

Same author

Correlation of reorientational jumps of water molecules in bulk water.

Physical review. E, Statistical, nonlinear, and soft matter physics·2013

Same author

Palladium-catalyzed direct arylation of C-H bond to construct quaternary carbon centers: the synthesis of diarylfluorene.

Organic letters·2013

Same author

Strength and fracture behavior of graphene grain boundaries: effects of temperature, inflection, and symmetry from molecular dynamics.

Physical chemistry chemical physics : PCCP·2013

Search research articles

Related Experiment Video

Updated: Jul 15, 2025

Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties

Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties

Published on: May 19, 2023

Understanding cervical cancer at single-cell resolution.

Shengqin Yue¹, Qian Wang¹, Jiajun Zhang¹

¹Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

|September 28, 2023

Summary

Single-cell sequencing reveals the complex tumor ecosystem in cervical cancer, offering insights into its evolution and guiding personalized treatment strategies for better patient outcomes.

Keywords:

Cancer ecosystem Cervical cancer Heterogeneity Immunotherapy Single-cell sequencing

More Related Videos

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Published on: May 14, 2019

Single-Cell Resolution Three-Dimensional Imaging of Intact Organoids

Single-Cell Resolution Three-Dimensional Imaging of Intact Organoids

Published on: June 5, 2020

Related Experiment Videos

Last Updated: Jul 15, 2025

Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties

Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties

Published on: May 19, 2023

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Published on: May 14, 2019

Single-Cell Resolution Three-Dimensional Imaging of Intact Organoids

Single-Cell Resolution Three-Dimensional Imaging of Intact Organoids

Published on: June 5, 2020

Area of Science:

Oncology
Genomics
Cancer Biology

Background:

Cervical cancer is a significant global health issue, ranking as the fourth most common cancer in women.
Tumor ecosystem heterogeneity critically influences cancer development, progression, and treatment response.
Understanding this ecosystem is essential for improving patient prognoses.

Purpose of the Study:

To review recent advancements in single-cell sequencing for dissecting cervical cancer ecosystem heterogeneity.
To elucidate the dynamic changes within the cervical cancer ecosystem during different stages of the disease and treatment.

Main Methods:

Leveraging single-cell sequencing technologies to analyze cervical cancer at an unprecedented resolution.
Comprehensive review of current literature on single-cell studies in cervical cancer research.

Main Results:

Single-cell sequencing provides a high-resolution view of cervical cancer's cellular and molecular complexity.
Detailed insights into the evolution of the tumor microenvironment from initiation through progression and treatment.

Conclusions:

High-resolution single-cell analysis is crucial for understanding cervical cancer heterogeneity.
This approach has the potential to accelerate the development of targeted therapies and personalized medicine for cervical cancer patients.