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TransFLP — A Method to Genetically Modify Vibrio cholerae Based on Natural Transformation and FLP-recombination
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TransFLP — A Method to Genetically Modify Vibrio cholerae Based on Natural Transformation and FLP-recombination

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Phage for treatment of Vibrio cholerae infection

Milky Mittal1, Surbhi Tripathi1, Ashok Saini2

  • 1Dr. B.R. Ambedkar Centre for Biomedical Research, University of Delhi, New Delhi, India.

Progress in Molecular Biology and Translational Science
|September 28, 2023
PubMed

Insights

Bacteriophages (phages), natural bacterial enemies, show promise in combating multidrug-resistant Vibrio species causing cholera. Phage therapy offers a potential solution to antibiotic resistance challenges.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biotechnology

Background:

  • Cholera, caused by Vibrio species, has led to global pandemics.
  • Antibiotics were primary treatments but face challenges from multidrug resistance.
  • Bacterial resistance to antibiotics is a significant global health concern.

Purpose of the Study:

  • To highlight the potential of bacteriophages (phages) as an alternative to antibiotics.
  • To explore phage therapy for combating Vibrio-related infectious diseases.
  • To discuss phage-based vaccination as a preventive strategy.

Main Methods:

  • Taxonomic evaluation of phages based on their antibacterial properties.
  • Review of current research on phage therapy and phage-based vaccination.
  • Analysis of bacteriophages as a solution to antibiotic resistance.

Main Results:

  • Bacteriophages are ubiquitous and represent a natural defense against bacteria.
  • Phage therapy is emerging as a promising approach to combat drug-resistant bacteria.
  • Phage-based vaccination is a developing preventive strategy with significant potential.

Conclusions:

  • Bacteriophages offer a viable alternative to antibiotics for treating bacterial infections.
  • Phage therapy is a critical area of research for addressing the challenge of antimicrobial resistance.
  • Further research into bacteriophages is essential for developing novel strategies against Vibrio infections.
Keywords:
CholeraPathogenicityPhage therapyPhagesVibrioVirulence

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