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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.3K

COVID-19 and cardiovascular disease in patients with chronic kidney disease

Lucia Del Vecchio1, Olga Balafa2, Evangelia Dounousi3

  • 1Department of Nephrology and Dialysis, Sant'Anna Hospital, ASST Lariana, Como, Italy.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|September 29, 2023
PubMed

Insights

Chronic kidney disease (CKD) patients face higher risks for cardiovascular (CV) complications from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This review examines these CV issues in CKD patients, including those on dialysis or post-transplant.

Area of Science:

  • Nephrology
  • Cardiology
  • Infectious Diseases

Background:

  • Chronic kidney disease (CKD) significantly elevates cardiovascular (CV) disease risk.
  • CKD patients, especially those on dialysis or kidney recipients, experience more severe outcomes from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.
  • Coronavirus disease 2019 (COVID-19) presents numerous CV complications, including inflammation, events, thrombosis, and arrhythmias.

Approach:

  • This review synthesizes current knowledge on cardiovascular complications associated with COVID-19.
  • It specifically analyzes the implications of these complications for individuals with chronic kidney disease.
  • The review explores proposed pathogenetic mechanisms underlying these CV issues.

Key Points:

  • CKD is a major risk factor for severe COVID-19 and subsequent cardiovascular complications.
  • Cardiovascular manifestations of COVID-19 in CKD patients range from acute inflammatory responses to long-term events.
  • Potential mechanisms include direct viral effects, endothelial dysfunction, and hypercoagulability.

Conclusions:

  • COVID-19 poses a substantial threat to cardiovascular health in the CKD population.
  • Understanding these risks is crucial for managing CKD patients during and after the pandemic.
  • Further research is needed to elucidate specific mechanisms and develop targeted interventions.

Keywords:
COVID-19SARS-Cov2cardiovascular diseasechronic kidney diseasepost-COVID syndrome

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