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Metaplastic carcinoma with osteosarcomatous differentiation in the breast: Case report
Belinda Asare1, Marissa Janine White1, Joanna Rossi1
1Johns Hopkins University School of Medicine, 601 N. Caroline St, Baltimore, MD 21287, USA.
Radiology Case Reports
|September 29, 2023
Summary
Metaplastic breast carcinoma, a rare and aggressive cancer, can recur with osteosarcomatous features. Early recognition of its varied presentation is key for timely diagnosis and evolving treatment.
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Metaplastic breast carcinoma (MBC) is a rare, aggressive breast cancer subtype.
- It often presents distinct histopathological features, including osteosarcomatous differentiation.
- Previous treatment for invasive ductal carcinoma (IDC) can precede MBC recurrence.
Observation:
- A case of recurrent MBC with osteosarcomatous differentiation is presented.
- The patient had a history of invasive ductal carcinoma and partial mastectomy.
- A new palpable mass with calcifications near the prior surgery site was noted.
Findings:
- Imaging revealed a mass with calcifications, potentially mimicking benign findings.
- Histopathology confirmed metaplastic breast carcinoma with osteosarcomatous elements.
- The clinical course following treatment was documented.
Implications:
- Recognizing the diverse presentations of MBC, including benign-appearing imaging findings, is crucial.
- Timely diagnosis of this rare subtype impacts treatment strategies.
- Understanding MBC's evolution aids in managing recurrent disease.
