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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

474
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
474
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

555
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
555

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Related Experiment Video

Updated: Jul 15, 2025

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
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Steroid Response Following Dropless Cataract Surgery Using Subconjunctival Triamcinolone.

Annie M Wu1,2, Kristen M Pitts1,3, Roberto Pineda1

  • 1Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Clinical Ophthalmology (Auckland, N.Z.)
|September 29, 2023
PubMed
Summary
This summary is machine-generated.

Dropless cataract surgery may increase the risk of prolonged steroid response, particularly in patients with glaucoma. This finding suggests caution when considering dropless procedures for these individuals.

Keywords:
glaucomaintraocular pressureocular hypertensionpostoperativetriamcinolone depot

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Area of Science:

  • Ophthalmology
  • Surgical Innovation
  • Pharmacology

Background:

  • Cataract surgery is a common procedure with various postoperative management strategies.
  • Steroid response, characterized by elevated intraocular pressure (IOP), is a known complication.
  • Dropless cataract surgery aims to simplify postoperative care by using subconjunctival steroid depots.

Purpose of the Study:

  • To compare the rates of postoperative steroid response between dropless cataract surgery (subconjunctival triamcinolone) and conventional cataract surgery (topical prednisolone).
  • To identify risk factors associated with steroid response after cataract surgery.

Main Methods:

  • A retrospective review of consecutive cataract surgery cases (dropless vs. conventional) was conducted.
  • Steroid response was defined as a 50% increase in IOP above baseline or IOP > 24 mmHg, excluding the first 72 hours postoperatively.
  • Logistic regression models were used to analyze risk factors and outcomes.

Main Results:

  • A higher proportion of eyes undergoing dropless surgery developed a steroid response (10% vs. 5%), though not statistically significant (P=0.096).
  • Significant risk factors for steroid response included dropless surgery (OR=2.43) and a prior diagnosis of glaucoma (OR=7.18).
  • Dropless cases showed a higher incidence of prolonged IOP elevation (≥30 days).

Conclusions:

  • Dropless cataract surgery, utilizing subconjunctival triamcinolone, is associated with an increased risk of prolonged postoperative steroid response.
  • Patients with a history of glaucoma are at significantly higher risk for steroid response and may not be suitable candidates for this type of dropless surgery.