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Post-COVID-19 cholangiopathy: Systematic review.
Mazen Abdalla Rasheed1, Vinícius Remus Ballotin2, Lucas Goldmann Bigarella2
1Acute Medicine, University of South Wales, Cardiff CF37 1DL, United Kingdom.
World Journal of Methodology
|September 29, 2023
Summary
COVID-19 can cause secondary sclerosing cholangitis (SC), known as post-COVID-19 cholangiopathy. This serious condition requires further research into treatments like liver transplantation.
Area of Science:
- Hepatology
- Infectious Diseases
- Gastroenterology
Background:
- COVID-19 primarily causes respiratory illness but can lead to secondary sclerosing cholangitis (SC), termed post-COVID-19 cholangiopathy.
- Emerging evidence highlights the potential for COVID-19 to trigger this serious liver condition.
Purpose of the Study:
- To synthesize existing case reports and assess the current understanding of post-COVID-19 cholangiopathy.
- To consolidate knowledge on this emerging complication of COVID-19.
Main Methods:
- Comprehensive literature search using Medical Subject Headings and Health Sciences Descriptors across major databases (Scopus, Web of Science, PubMed).
- Inclusion of studies in English, Spanish, or Portuguese, with manual reference list searching.
- Descriptive analysis and Reference Citation Analysis for data summarization and assessment.
Main Results:
- Analysis of 63 full-length articles revealed that most affected patients were male with elevated liver function tests (93.8%).
- Imaging showed duct thickening (47.7%) and intrahepatic duct beading (45.7%); liver biopsies confirmed SC in 74.4% of cases.
- Sixteen patients underwent liver transplantation, with three successful outcomes reported.
Conclusions:
- Post-COVID-19 cholangiopathy is a significant and growing concern, especially with the rise of long COVID syndromes.
- Liver transplantation is a potential treatment, but further research is crucial to determine its efficacy and explore alternative therapies.
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