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Neurovascular function in the rat during pregnancy.

J L Hart, W Freas, S M Muldoon

The American Journal of Physiology

|November 1, 1986

Summary

Pregnancy does not alter vascular neuroeffector junction function in rats. Norepinephrine (NE) release, receptor sensitivity, and NE accumulation remain unchanged, suggesting other mechanisms regulate maternal circulation changes.

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Area of Science:

Physiology
Cardiovascular Research
Neuropharmacology

Background:

Sympathetic control of maternal circulation is altered during pregnancy.
The vascular neuroeffector junction is a key site for sympathetic neurotransmission.

Purpose of the Study:

To investigate if changes in vascular neuroeffector junction activity in pregnant rats explain altered sympathetic control.
To compare neuroeffector function in caudal and mesenteric arteries of pregnant and nonpregnant rats.

Main Methods:

Isometric tension recording of rat caudal and mesenteric arteries.
Frequency-response and concentration-response measurements for norepinephrine (NE) and tyramine.
Assessment of NE content and [3H]NE accumulation in caudal arteries.

Main Results:

Both caudal and mesenteric arteries showed similar responses to NE, tyramine, and electrical stimulation in pregnant (PG) and nonpregnant (NPG) rats.
NE content, [3H]NE accumulation, and plasma effects on [3H]NE accumulation were comparable between PG and NPG caudal arteries.
Vascular neuroeffector functions, including NE release, receptor sensitivity, and NE accumulation, are not modified during rat pregnancy.

Conclusions:

Pregnancy does not alter vascular neuroeffector junction function in rats.
Altered sympathetic control of maternal circulation during pregnancy likely involves mechanisms beyond the neuroeffector junction.

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