Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatic splanchnic function in acutely hypoxemic humans at rest.

J R Blackmon, L B Rowell

    The American Journal of Physiology
    |November 1, 1986
    PubMed
    Summary

    Splanchnic metabolism remains stable during hypoxemia, with consistent oxygen uptake and glucose/lactate exchange. However, hepatic extraction of indocyanine green significantly decreased under low oxygen conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Commentaries.

    Canadian Medical Association journal·2010
    Same author

    Commentaries.

    Canadian Medical Association journal·2010
    Same author

    Commentaries.

    Canadian Medical Association journal·2010
    Same author

    Exercising testing in adult normal subjects and cardiac patients. 1963.

    Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·2004
    Same author

    Muscle chemoreflex alters carotid sinus baroreflex response in humans.

    Journal of applied physiology (Bethesda, Md. : 1985)·1997
    Same author

    Neural control of muscle blood flow: importance during dynamic exercise.

    Clinical and experimental pharmacology & physiology·1997

    Area of Science:

    • Physiology
    • Metabolic Studies
    • Hypoxia Research

    Background:

    • Splanchnic (visceral) organs play a crucial role in overall body metabolism.
    • Understanding how these organs function under stress, such as hypoxemia (low oxygen), is vital for clinical management.
    • Previous research has indicated potential alterations in hepatic function during reduced oxygen availability.

    Purpose of the Study:

    • To investigate the impact of moderate and severe hypoxemia on splanchnic oxygen consumption, glucose release, and lactate uptake.
    • To evaluate the hepatic extraction, removal, and clearance of catecholamines (norepinephrine and epinephrine) under varying oxygen levels.
    • To identify any specific hepatic functions that are compromised during hypoxemia.

    Main Methods:

    • Studied splanchnic oxygen, glucose, and lactate metabolism in normal men under normoxia and two levels of hypoxemia (10.4% and 7.6% O2).
    • Measured hepatic extraction efficiency, removal rate, and clearance of norepinephrine and epinephrine using radioenzymatic assay during normoxia and hypoxemia.
    • Assessed hepatic extraction of indocyanine green in all subjects under both normoxic and hypoxemic conditions.

    Main Results:

    • Splanchnic oxygen uptake and arteriovenous oxygen difference remained constant despite reduced arterial oxygen content.
    • Hepatic glucose release and lactate uptake were unaffected by moderate or severe hypoxemia.
    • Hepatic removal and clearance of norepinephrine and epinephrine were not influenced by hypoxemia, although extraction efficiency for norepinephrine increased.
    • A significant decrease in indocyanine green extraction was observed in all subjects during hypoxemia.

    Conclusions:

    • The splanchnic organs maintain essential metabolic functions like oxygen, glucose, and lactate exchange even under significant hypoxemia.
    • Hepatic handling of catecholamines remains largely intact during hypoxemia, with some adaptive changes in extraction efficiency.
    • Hepatic extraction of indocyanine green is a sensitive indicator of hepatic dysfunction under hypoxemic stress.

    Related Experiment Videos