Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vitamins01:30

Vitamins

765
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
765
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

16
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
16
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

348
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
348
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

481
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
481
Minerals01:26

Minerals

344
Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
 
Major...
344
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

614
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
614

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic Accuracy of Exchangeable Copper for Grading the Severity of Wilson Disease.

Journal of inherited metabolic disease·2026
Same author

Transition from zinc salts to trientine tetrahydrochloride in a cohort of adult patients with Wilson disease: the ZICUP study.

Orphanet journal of rare diseases·2026
Same author

Evaluation of novel assays of non-ceruloplasmin copper to monitor chelation treatment in patients with Wilson disease.

JHEP reports : innovation in hepatology·2026
Same author

Impact of COVID-19 infection in patients with inherited metabolic diseases: a National Multicenter Study from the French IMDs Healthcare Network for Rare Diseases.

Orphanet journal of rare diseases·2026
Same author

Diagnostic utility of clinical neurophysiology in Wilson's disease with hyperkinetic movements.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

Modified Unified Wilson's Disease Rating Scale - scale presentation and pilot clinimetric testing.

Neurologia i neurochirurgia polska·2025

Related Experiment Video

Updated: Jul 15, 2025

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
06:52

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Published on: April 28, 2023

1.4K

Can Patients with Wilson's Disease Develop Copper Deficiency?

Kevin Chevalier1,2, Mickaël Alexandre Obadia1,2, Nouzha Djebrani-Oussedik2,3

  • 1Department of Neurology Rothschild Foundation Hospital Paris France.

Movement Disorders Clinical Practice
|September 29, 2023
PubMed
Summary

Wilson's disease patients may develop copper deficiency (CD) after long-term zinc treatment. Anemia and neutropenia are key indicators of this condition, requiring careful monitoring and treatment adaptation.

Keywords:
Wilson's diseaseanemiacopper deficiencymyeloneuropathyzinc salts

More Related Videos

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

9.2K
Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
13:04

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

38.7K

Related Experiment Videos

Last Updated: Jul 15, 2025

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
06:52

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Published on: April 28, 2023

1.4K
Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

9.2K
Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
13:04

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

38.7K

Area of Science:

  • Medical Genetics
  • Neurology
  • Hematology

Background:

  • Wilson's disease (WD) results from ATP7B gene mutations, causing copper overload.
  • Lifelong decoppering treatments are essential but require careful management to prevent copper deficiency (CD).

Purpose of the Study:

  • To investigate the characteristics of copper deficiency (CD) in patients with Wilson's disease (WD).

Main Methods:

  • Investigated CD cases in a cohort of 338 WD patients.
  • Defined CD using serum copper, exchangeable copper, and urinary copper excretion assays, alongside cytopenia and/or neurological damage.
  • Conducted a systematic literature review of CD in WD patients.

Main Results:

  • Identified 3 WD patients with CD in the cohort and 17 from literature review.
  • Most patients presented with anemia and neutropenia, often with neurological symptoms like posterior cord syndrome.
  • Zinc salt treatment adaptation corrected cytopenia but only partially improved neurological symptoms.

Conclusions:

  • Copper deficiency (CD) can manifest in Wilson's disease (WD) patients after years of zinc therapy.
  • Anemia and neutropenia are critical warning signs for CD in WD patients.