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Prospective motion correction for cervical spinal cord MRS.

Isaac M Adanyeguh1, Pierre-Gilles Henry1, Dinesh K Deelchand1

  • 1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.

Magnetic Resonance in Medicine
|September 29, 2023
PubMed
Summary

Prospective motion correction using MR navigators significantly improves single-voxel magnetic resonance spectroscopy (MRS) quality in the human cervical spinal cord. This technique minimizes lipid contamination, enabling reliable research and clinical applications.

Keywords:
3 Tprospective motion correctionspectroscopyspinal cord

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Area of Science:

  • Medical Imaging
  • Neuroimaging

Background:

  • Single-voxel magnetic resonance spectroscopy (MRS) is crucial for assessing the human cervical spinal cord.
  • Motion artifacts, particularly lipid contamination, degrade spectral quality and hinder clinical utility.

Purpose of the Study:

  • To develop and validate a prospective motion correction technique for single-voxel MRS in the human cervical spinal cord.
  • To assess the impact of motion correction on spectral quality in the presence of subject motion.

Main Methods:

  • Implemented a motion MR navigator with reduced field-of-view 2D-selective RF excitation and EPI readout.
  • Integrated the motion navigator with a short-echo semi-LASER sequence, including real-time shim and frequency navigators.
  • Acquired single-voxel MRS data from C3-5 vertebrae in five healthy participants at 3T, correcting for X-Y plane translations.

Main Results:

  • Without prospective correction, subject motion caused severe lipid contamination in MR spectra.
  • Prospective correction maintained spectral quality comparable to no-motion scans, with similar signal-to-noise ratio, linewidth, and no significant lipid contamination.

Conclusions:

  • Prospective motion and B0 correction enable high-quality MR spectra acquisition in the moving human cervical spinal cord.
  • This technique is expected to enhance the reliability of spinal cord MRS in research and clinical settings.