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Drugs and stillbirth.

J B Porter, J Hunter-Mitchell, H Jick

American Journal of Public Health

|December 1, 1986

Summary

This study found no link between common medications like oral contraceptives, spermicides, or antibiotics used before pregnancy and stillbirths. Researchers investigated 73 cases to assess potential risks. Keywords: stillbirth, pregnancy, oral contraceptives, antibiotics, spermicides.

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Area of Science:

Obstetrics and Gynecology
Reproductive Health
Perinatal Epidemiology

Background:

Perinatal mortality, including stillbirths, is a significant concern in public health.
Identifying risk factors for stillbirth is crucial for developing effective prevention strategies.
Previous research has explored various maternal exposures, but conclusive evidence on certain medications remains limited.

Purpose of the Study:

To investigate potential associations between preconception use of spermicides, oral contraceptives, Bendectin, and antibiotics and the risk of nontraumatic stillbirth.
To provide data to inform clinical practice and patient counseling regarding medication use during the reproductive years.

Main Methods:

A case-control study design was employed.
Data were collected over a five-year period at Group Health Cooperative of Puget Sound.
The study included 73 cases of nontraumatic stillbirth.

Main Results:

No plausible association was demonstrated between the use of spermicides prior to conception and stillbirth.
No plausible association was demonstrated between the use of oral contraceptives prior to conception and stillbirth.
No plausible association was demonstrated between the use of Bendectin or antibiotics prior to conception and stillbirth.

Conclusions:

The findings suggest that preconception use of spermicides, oral contraceptives, Bendectin, and antibiotics is not associated with an increased risk of nontraumatic stillbirth.
Further research may be warranted to explore other potential risk factors.
These results can help alleviate patient concerns regarding the use of these common medications before pregnancy.

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